Spinals in THA (Total Hip Arthroplasty)

Conditions:Arthritis, Osteoarthritis (OA)
Therapuetic Areas:Rheumatology
Age Range:18 - 90
Start Date:September 2016
End Date:November 2019
Contact:Ashley Freeman

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Comparison of Lidocaine Versus Bupivacaine Spinal Anesthesia in Total Hip Arthroplasty: A Randomized, Double-Blind, Prospective Study

Spinal anesthesia is commonly used in patients undergoing total hip replacements. The purpose
of this study is to compare lidocaine to bupivacaine spinal anesthesia in patients having a
total hip arthroplasty (THA). The objective of this study is to compare the two spinal
anesthesia treatments in regards to transient neurological symptoms (TNS).

Participants will have their patient records examined prospectively and complete up to four
telephone questionnaires after randomization to lidocaine or bupivacaine spinal anesthesia to
see how they are feeling after their total hip arthroplasty (THA). Transient neurological
symptoms, urinary retention, timing of full mobilization, incidence of hypotension, and
length of hospital stay will be recorded for both methods of spinal anesthesia for

Inclusion Criteria:

- Radiographic evidence of symptomatic osteoarthritis in one or bilateral hips.
Osteoarthritis will be defined as pain with weight-bearing at the hip articulation
together with radiographic findings

- Indicated for total hip arthroplasty

- Agreement to undergo spinal anesthesia for surgery

Exclusion Criteria:

- Patient refusal to undergo spinal anesthesia

- Patients with a known history of lumbar or sacral spinal fusion.

- Patients with a known history of prostate, urological, or kidney surgery.

- Patients who need monitoring of urine output during surgery (including patients with
confirmed renal disease, renal failure, chronic renal insufficiency, or an indwelling
catheter at the time of surgery).

- Current infection at site of injection

- Women of child-bearing potential who are on Medicare (child-bearing potential will be
determined prior to surgery per Anesthesia standard of care)

- Hypovolemia

- Indeterminate neurologic disease

- Allergy or hypersensitivity to the study medications

- Currently taking any anti-coagulation medications or coagulopathic

- Increased intracranial pressure

- Subject is unable to make his/her own decision regarding the informed consent

- Subject is unable to read/understand English
We found this trial at
Atlanta, Georgia 30322
Principal Investigator: Thomas Bradbury, MD
Atlanta, GA
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1455 Montreal Road East
Atlanta, Georgia 30329
Principal Investigator: Thomas Bradbury, MD
Atlanta, GA
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