A Study Of Oral PF-02341066, A C-Met/Hepatocyte Growth Factor Tyrosine Kinase Inhibitor, In Patients With Advanced Cancer



Status:Recruiting
Conditions:Lung Cancer, Cancer, Lymphoma
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:3/22/2019
Start Date:April 19, 2006
End Date:November 11, 2019
Contact:Pfizer CT.gov Call Center
Email:ClinicalTrials.gov_Inquiries@pfizer.com
Phone:1-800-718-1021

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PHASE 1 SAFETY, PHARMACOKINETIC AND PHARMACODYNAMIC STUDY OF PF-02341066, A C-MET/HGFR SELECTIVE TYROSINE KINASE INHIBITOR, ADMINISTERED ORALLY TO PATIENTS WITH ADVANCED CANCER

PF-02341066 may work in cancer by blocking the cell growth, migration and invasion of tumor
cells. PF-02341066 is a new class of drugs called c-Met/Hepatocyte growth factor receptor
tyrosine kinase inhibitors. This compound is also an inhibitor of the anaplastic lymphoma
kinase (called ALK) tyrosine kinase and ROS receptor tyrosine kinases. This research study is
the first time PF-02341066 will be given to people. PF-02341066 is taken by mouth daily.


Inclusion Criteria:

- Advanced malignancies (except leukemias), histologically proven at diagnosis;
Histologically confirmed advanced malignancies that are known to be sensitive to
PF-03241066 inhibition, e.g. ALK, c-MET and ROS

- Solid tumors must have measurable disease (Recommended Phase 2 Dose Cohort patients
with non-measurable disease may enter on a case-by-case basis); not required for DDI
sub-studies.

- Adequate blood cell counts, kidney function, liver function and Eastern Cooperative
Oncology Group (ECOG) score of 0 or 1 (for the Recommended Phase 2 Cohort, a ECOG
score of 2 may be allowed on a case-by-case basis)

Exclusion Criteria:

- Major surgery, radiation therapy or anti-cancer therapy within 2 to 4 weeks of
starting study treatment, depending on the patient cohort

- Prior stem cell transplant except of patients with neuroblastoma, lymphoma or myeloma

- Active or unstable cardiac disease or heart attack within 3 months of starting study
treatment
We found this trial at
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Chapel Hill, North Carolina 27514
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185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
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330 Brookline Ave
Boston, Massachusetts 02215
617-667-7000
Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) is one of the...
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5801 South Ellis Avenue
Chicago, Illinois 60637
 773.702.1234
University of Chicago One of the world's premier academic and research institutions, the University of...
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12605 East 16th Avenue
Aurora, Colorado 80045
720-848-0000
University of Colorado Hospital, Site Top medical professionals, superior medicine and progressive change make University...
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Aurora, Colorado 80045
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Boston, Massachusetts 02114
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Boston, Massachusetts 02115
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Boston, Massachusetts 02215
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Burlington, Vermont 05405
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Burlington, Vermont 05405
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Burlington, Vermont 05401
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Chapel Hill, North Carolina 27599
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Columbus, OH
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915 Olentangy River Road
Columbus, Ohio 43212
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Detroit, Michigan 48201
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Detroit, Michigan 48201
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Melbourne, Victoria 3004
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Nashville, Tennessee 37232
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Nashville, Tennessee 37232
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Nashville, Tennessee 37232
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1275 York Ave
New York, New York 10021
(212) 639-2000
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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1275 York Ave
New York, New York 10021
(212) 639-2000
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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300 East 66th Street
New York, New York 10065
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101 The City Drive South
Orange, California 92868
714-456-7890
University of California, Irvine Medical Center We are UC Irvine Health. We are a devoted...
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Pittsburgh, Pennsylvania 15232
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