A Study to Determine the Efficacy and Safety of Fasinumab for the Treatment of Adults With Chronic Low Back Pain

Key Inclusion Criteria:

1. Male or female ≥35 years of age at the screening visit

2. Clinical diagnosis of chronic moderate to severe LBP (nonradiculopathic)for ≥3 months

3. History of regular analgesic medication

4. History of inadequate pain relief or intolerance to analgesics used for chronic LBP

5. Willing to discontinue current pain medication

Key Exclusion Criteria:

1. History of lumbosacral radiculopathy within the past 2 years

2. Evidence on baseline lumbar spine magnetic resonance imaging of potentially
confounding conditions

3. Recent use of longer acting pain medications

4. Evidence of destructive arthropathy

5. Other medical conditions that may interfere with participation or accurate assessments
during the trial