Study of Safety and Efficacy of Brolucizumab 6 mg Drug Product Intended for Commercialization in Patients With nAMD



Status:Completed
Conditions:Ocular
Therapuetic Areas:Ophthalmology
Healthy:No
Age Range:50 - Any
Updated:2/20/2019
Start Date:January 15, 2018
End Date:September 6, 2018

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Trial Summary
Trial Overview
Inclusion Criteria

A 24-week, Double-masked, Multicenter, Two-arm Extension Study to Collect Safety and Efficacy Data on Brolucizumab 6 mg Drug Product Intended for Commercialization in Patients With Neovascular Age-related Macular Degeneration Who Have Completed the CRTH258A2301 Study

The purpose of this study is to collect data on safety and efficacy of the brolucizumab 6 mg
drug product intended for commercialization in patients with neovascular age-related macular
degeneration (nAMD) and to support comparability to the 6 mg drug product used in Phase III.


Inclusion Criteria:

- Sign written informed consent

- Completed the core study, CRTH258A2301

Exclusion Criteria:

- Patient discontinued the treatment or the core study prematurely at any time

- Patient received standard of care treatment for nAMD after completion of the core
study

- Pregnant or nursing women and women of child-bearing potential

- Other protocol-specified exclusion criteria may apply
We found this trial at
60
sites
Novartis Investigative Site
Richmond, Virginia 23249
344
mi
from 43215
Richmond, VA
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Novartis Investigative Site
Abilene, Texas 79606
1063
mi
from 43215
Abilene, TX
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Novartis Investigator Site
Albuquerque, New Mexico 87108
1330
mi
from 43215
Albuquerque, NM
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Novartis Investigative Site
Altamonte Springs, Florida 32701
786
mi
from 43215
Altamonte Springs, FL
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Novartis Investigative Site
Arcadia, California 91006
?
mi
from 43215
Arcadia, CA
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Novartis Investigative Site
Arecibo, 00612
?
mi
from 43215
Arecibo,
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Novartis Investigational Site
Austin, Texas 78759
1065
mi
from 43215
Austin, TX
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Novartis
Baltimore, Maryland 21287
345
mi
from 43215
Baltimore, MD
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Novartis Investigative Site
Bloomington, Illinois 61701
316
mi
from 43215
Bloomington, IL
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Novartis Investigative Site
Boise, Idaho 83712
1715
mi
from 43215
Boise, ID
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Novartis Investigative Site
Bridgeport, Connecticut 06606
521
mi
from 43215
Bridgeport, CT
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Novartis Investigative Site
Camp Hill, Pennsylvania 17011
323
mi
from 43215
Camp Hill, PA
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Novartis Investigative Site
Charlotte, North Carolina 28277
360
mi
from 43215
Charlotte, NC
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Novartis Investigative Site
Cleveland, Ohio 44109
123
mi
from 43215
Cleveland, OH
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Novartis Investigative Site
Colorado Springs, Colorado 80907
1162
mi
from 43215
Colorado Springs, CO
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Novartis Investigative Site
Deerfield Beach, Florida 33064
957
mi
from 43215
Deerfield Beach, FL
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Novartis Investigative Site
Dublin, Ohio 43016
10
mi
from 43215
Dublin, OH
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Novartis Investigative Site
Fairfield, Ohio 45014
92
mi
from 43215
Fairfield, OH
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Novartis Investigative Site
Fort Myers, Florida 33912
930
mi
from 43215
Fort Myers, FL
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Novartis Investigative Site
Fort Worth, Texas 76104
937
mi
from 43215
Fort Worth, TX
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Novartis Investigative Site
Golden, Colorado 80401
1174
mi
from 43215
Golden, CO
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Novartis Investigative Site
Houston, Texas 77030
995
mi
from 43215
Houston, TX
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Novartis Investigative Site
Huntington Beach, California 92647
1968
mi
from 43215
Huntington Beach, CA
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Novartis Investigative Site
Indianapolis, Indiana 46202
167
mi
from 43215
Indianapolis, IN
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Novartis Investigative Site
La Jolla, California 92037
1954
mi
from 43215
La Jolla, CA
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Novartis Investigative Site
Las Vegas, Nevada 89135
1756
mi
from 43215
Las Vegas, NV
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Novartis Investigative Site
Leawood, Kansas 66211
621
mi
from 43215
Leawood, KS
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Novartis Investigative Site
Loma Linda, California 92354
1919
mi
from 43215
Loma Linda, CA
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Novartis Investigator Site
Milwaukee, Wisconsin 53209
335
mi
from 43215
Milwaukee, WI
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Novartis Investigative Site
Morgantown, West Virginia 26506
164
mi
from 43215
Morgantown, WV
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Novartis Investigative Site
Mountain View, California 94040
2086
mi
from 43215
Mountain View, CA
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Novartis Investigative Site
Nashville, Tennessee 37205
339
mi
from 43215
Nashville, TN
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Novartis Investigative Site
New London, Connecticut 06320
579
mi
from 43215
New London, CT
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Novartis Investigative Site
Oakland, California 94612
2098
mi
from 43215
Oakland, CA
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Novartis Investigative Site
Ocala, Florida 34471
748
mi
from 43215
Ocala, FL
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Novartis Investigative Site
Palm Beach Gardens, Florida 33410
920
mi
from 43215
Palm Beach Gardens, FL
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Novartis Investigative Site
Pensacola, Florida 32504
695
mi
from 43215
Pensacola, FL
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Novartis Investigative Site
Peoria, Arizona 85381
1666
mi
from 43215
Peoria, AZ
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Novartis Investigative Site
Phoenix, Arizona 85012
1660
mi
from 43215
Phoenix, AZ
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Novartis Investigative Site
Plano, Texas 75024
899
mi
from 43215
Plano, TX
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Novartis Investigative Site
Portland, Maine 04102
702
mi
from 43215
Portland, ME
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Novartis Investigative Site
Redlands, California 92374
1915
mi
from 43215
Redlands, CA
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Novartis Investigative Site
Reno, Nevada 89502
1936
mi
from 43215
Reno, NV
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Novartis Investigative Site
Rochester, New York 14615
356
mi
from 43215
Rochester, NY
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Novartis Investigative Site
Sacramento, California 95825
2039
mi
from 43215
Sacramento, CA
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Novartis
San Antonio, Texas 78207
Novartis Novartis, which was created in 1996 by the merger of the Swiss companies Ciba-Geigy...
1139
mi
from 43215
San Antonio, TX
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Novartis Investigative Site
Sarasota, Florida 34239
874
mi
from 43215
Sarasota, FL
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Novartis Investigative Site
Shawnee Mission, Kansas 66204
?
mi
from 43215
Shawnee Mission, KS
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Novartis Investigative Site
Shirley, New York 11967
?
mi
from 43215
Shirley, NY
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Novartis Investigative Site
Silverdale, Washington 98383
2023
mi
from 43215
Silverdale, WA
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Novartis Investigative Site
Southern Pines, North Carolina 28387
?
mi
from 43215
Southern Pines, NC
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Novartis Investigative Site
Spokane, Washington 99202
1778
mi
from 43215
Spokane, WA
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Novartis Investigative Site
Syracuse, New York 13210
414
mi
from 43215
Syracuse, NY
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Novartis Investigative Site
Tallahassee, Florida 32308
658
mi
from 43215
Tallahassee, FL
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Novartis Investigative Site
Toms River, New Jersey 08755
466
mi
from 43215
Toms River, NJ
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Novartis Investigative Site
University Place, Washington 98467
2017
mi
from 43215
University Place, WA
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Novartis Investigative Site
Vero Beach, Florida 32960
864
mi
from 43215
Vero Beach, FL
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Novartis Investigative Site
Waldorf, Maryland 20602
340
mi
from 43215
Waldorf, MD
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Novartis Investigative Site
Warrenton, Virginia 20186
292
mi
from 43215
Warrenton, VA
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Novartis Investigative Site
Winter Haven, Florida 33880
828
mi
from 43215
Winter Haven, FL
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