An Investigational Immunotherapy Study of Nivolumab With Standard of Care Therapy vs Standard of Care Therapy for First-Line Treatment of Colorectal Cancer That Has Spread



Status:Recruiting
Conditions:Colorectal Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:12/16/2018
Start Date:February 14, 2018
End Date:August 18, 2022
Contact:Recruiting sites have contact information. Please contact the sites directly. If there is no contact information,
Email:Clinical.Trials@bms.com
Phone:please email:

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An Open-Label Exploratory Phase 2/3 Study of Nivolumab With Standard of Care Therapy vs Standard of Care Therapy for First-Line Treatment of Metastatic Colorectal Cancer

This purpose of this study is to evaluate nivolumab (BMS-936558) in combination with standard
of care (SOC) chemotherapy with bevacizumab for the treatment of first-line metastatic
colorectal cancer (mCRC).


For more information regarding BMS clinical trial participation, please visit
www.BMSStudyConnect.com

Inclusion Criteria:

- Histologically confirmed metastatic colorectal cancer, not amenable to curative
resection

- No prior chemotherapy for metastatic colorectal cancer

- ECOG Performance Status of 0-1

- Ability to provide adequate tissue sample

Exclusion Criteria:

- Patients with clinically relevant medical history, including autoimmune disease,
cardiovascular disease, hepatic disease or bleeding disorders

- Prior treatment with an anti-PD-1, anti-PD-L1, anti-PD-L2, or anti-CTLA-4 antibody, or
any other antibody or drug specifically targeting T-cell co-stimulation or checkpoint
pathways

- Any positive test result for hepatitis B virus or hepatitis C virus indicating
presence of virus

Other protocol defined inclusion/exclusion criteria could apply
We found this trial at
42
sites
450 Brookline Ave
Boston, Massachusetts 2215
617-632-3000
Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
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Boston, MA
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1802 6th Avenue South
Birmingham, Alabama 35294
(205) 934-4011
UAB Comprehensive Cancer Center One of the nation’s leading cancer research and treatment centers, the...
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Birmingham, AL
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185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
Phone: 617-724-4000
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Boston, MA
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Arlington Heights, Illinois 60005
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Arlington Heights, IL
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Aurora, Colorado 80045
Phone: 303-724-3842
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Bedford, Texas 76022
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Bethesda, Maryland 20817
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Boston, Massachusetts 02215
Phone: 617-975-7409
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55 Fruit Street
Boston, Massachusetts 02215
Phone: 617-724-9347
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Boston, MA
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Charlotte, North Carolina 28211
Phone: 980-442-2346
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Charlotte, NC
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Chattanooga, Tennessee 37403
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Chattanooga, Tennessee 37403
Phone: 423-778-7821
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Dallas, TX
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Denver, Colorado 80218
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Edmonton, Alberta
Phone: 7804328285
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Fort Worth, Texas 76104
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Indianapolis, Indiana 46260
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Indianapolis, Indiana 46254
Phone: 317-297-2208
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Indianapolis, IN
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Jacksonville, Florida 32256
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Johnson City, New York 13790
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Longview, Texas 75601
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1441 Eastlake Ave
Los Angeles, California 90033
(323) 865-3000
Phone: 323-865-3967
U.S.C./Norris Comprehensive Cancer Center The USC Norris Comprehensive Cancer Center, located in Los Angeles, is...
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Madison, Wisconsin 53792
(608) 263-2400
Phone: 608-265-2789
University of Wisconsin In achievement and prestige, the University of Wisconsin–Madison has long been recognized...
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Miami, Florida 33176
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Minneapolis, Minnesota 55405
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250 25th Ave N, Ste 100
Nashville, Tennessee 37023
615-320-5090
Phone: 615-329-7274
Tennessee Oncology, PLLC Since 1976 Tennessee Oncology has been providing quality cancer care. In 2013,...
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Nashville, TN
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333 Cedar Street
New Haven, Connecticut 06520
(203) 785-4095
Yale Cancer Center Yale Cancer Center combines a tradition of innovative cancer treatment and quality...
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New Haven, CT
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New York, New York 10016
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New York, New York 10016
Phone: 212-731-5076
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Papillion, NE
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3451 Walnut St
Philadelphia, Pennsylvania 19104
1 (215) 898-5000
Phone: 215-220-9713
Univ of Pennsylvania Penn has a long and proud tradition of intellectual rigor and pursuit...
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PIttsburgh, Pennsylvania 15212
Phone: 412-359-8420
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Richmond, Virginia 23230
Phone: 804-287-3000
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Roanoke, VA
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Rochester, Minnesota 55905
Phone: 507-284-5280
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Saint Petersburg, Florida 33705
Phone: 813-875-3950
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San Antonio, Texas 78229
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San Diego, California 92123
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Santa Barbara, California 93105
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Sioux Falls, South Dakota 65104
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Tualatin, Oregon 97062
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