An Investigational Immunotherapy Study of Nivolumab With Standard of Care Therapy vs Standard of Care Therapy for First-Line Treatment of Colorectal Cancer That Has Spread



Status:Recruiting
Conditions:Colorectal Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:12/16/2018
Start Date:February 14, 2018
End Date:August 18, 2022
Contact:Recruiting sites have contact information. Please contact the sites directly. If there is no contact information,
Email:Clinical.Trials@bms.com
Phone:please email:

Use our guide to learn which trials are right for you!

An Open-Label Exploratory Phase 2/3 Study of Nivolumab With Standard of Care Therapy vs Standard of Care Therapy for First-Line Treatment of Metastatic Colorectal Cancer

This purpose of this study is to evaluate nivolumab (BMS-936558) in combination with standard
of care (SOC) chemotherapy with bevacizumab for the treatment of first-line metastatic
colorectal cancer (mCRC).


For more information regarding BMS clinical trial participation, please visit
www.BMSStudyConnect.com

Inclusion Criteria:

- Histologically confirmed metastatic colorectal cancer, not amenable to curative
resection

- No prior chemotherapy for metastatic colorectal cancer

- ECOG Performance Status of 0-1

- Ability to provide adequate tissue sample

Exclusion Criteria:

- Patients with clinically relevant medical history, including autoimmune disease,
cardiovascular disease, hepatic disease or bleeding disorders

- Prior treatment with an anti-PD-1, anti-PD-L1, anti-PD-L2, or anti-CTLA-4 antibody, or
any other antibody or drug specifically targeting T-cell co-stimulation or checkpoint
pathways

- Any positive test result for hepatitis B virus or hepatitis C virus indicating
presence of virus

Other protocol defined inclusion/exclusion criteria could apply
We found this trial at
42
sites
Bethesda, Maryland 20817
?
mi
from
Bethesda, MD
Click here to add this to my saved trials
1802 6th Avenue South
Birmingham, Alabama 35294
(205) 934-4011
UAB Comprehensive Cancer Center One of the nation’s leading cancer research and treatment centers, the...
?
mi
from
Birmingham, AL
Click here to add this to my saved trials
185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
Phone: 617-724-4000
?
mi
from
Boston, MA
Click here to add this to my saved trials
Arlington Heights, Illinois 60005
?
mi
from
Arlington Heights, IL
Click here to add this to my saved trials
Aurora, Colorado 80045
Phone: 303-724-3842
?
mi
from
Aurora, CO
Click here to add this to my saved trials
Bedford, Texas 76022
?
mi
from
Bedford, TX
Click here to add this to my saved trials
Boston, Massachusetts 02215
Phone: 617-975-7409
?
mi
from
Boston, MA
Click here to add this to my saved trials
55 Fruit Street
Boston, Massachusetts 02215
Phone: 617-724-9347
?
mi
from
Boston, MA
Click here to add this to my saved trials
450 Brookline Ave
Boston, Massachusetts 2215
617-632-3000
Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
?
mi
from
Boston, MA
Click here to add this to my saved trials
Charlotte, North Carolina 28211
Phone: 980-442-2346
?
mi
from
Charlotte, NC
Click here to add this to my saved trials
Chattanooga, Tennessee 37403
?
mi
from
Chattanooga, TN
Click here to add this to my saved trials
Chattanooga, Tennessee 37403
Phone: 423-778-7821
?
mi
from
Chattanooga, TN
Click here to add this to my saved trials
?
mi
from
Dallas, TX
Click here to add this to my saved trials
Denver, Colorado 80218
?
mi
from
Denver, CO
Click here to add this to my saved trials
Edmonton, Alberta
Phone: 7804328285
?
mi
from
Edmonton,
Click here to add this to my saved trials
Fort Worth, Texas 76104
?
mi
from
Fort Worth, TX
Click here to add this to my saved trials
?
mi
from
Henderson, NV
Click here to add this to my saved trials
Indianapolis, Indiana 46260
?
mi
from
Indianapolis, IN
Click here to add this to my saved trials
Indianapolis, Indiana 46254
Phone: 317-297-2208
?
mi
from
Indianapolis, IN
Click here to add this to my saved trials
Jacksonville, Florida 32256
?
mi
from
Jacksonville, FL
Click here to add this to my saved trials
Johnson City, New York 13790
?
mi
from
Johnson City, NY
Click here to add this to my saved trials
Longview, Texas 75601
?
mi
from
Longview, TX
Click here to add this to my saved trials
1441 Eastlake Ave
Los Angeles, California 90033
(323) 865-3000
Phone: 323-865-3967
U.S.C./Norris Comprehensive Cancer Center The USC Norris Comprehensive Cancer Center, located in Los Angeles, is...
?
mi
from
Los Angeles, CA
Click here to add this to my saved trials
Madison, Wisconsin 53792
(608) 263-2400
Phone: 608-265-2789
University of Wisconsin In achievement and prestige, the University of Wisconsin–Madison has long been recognized...
?
mi
from
Madison, WI
Click here to add this to my saved trials
Miami, Florida 33176
?
mi
from
Miami, FL
Click here to add this to my saved trials
Minneapolis, Minnesota 55405
?
mi
from
Minneapolis, MN
Click here to add this to my saved trials
250 25th Ave N, Ste 100
Nashville, Tennessee 37023
615-320-5090
Phone: 615-329-7274
Tennessee Oncology, PLLC Since 1976 Tennessee Oncology has been providing quality cancer care. In 2013,...
?
mi
from
Nashville, TN
Click here to add this to my saved trials
333 Cedar Street
New Haven, Connecticut 06520
(203) 785-4095
Yale Cancer Center Yale Cancer Center combines a tradition of innovative cancer treatment and quality...
?
mi
from
New Haven, CT
Click here to add this to my saved trials
New York, New York 10016
?
mi
from
New York, NY
Click here to add this to my saved trials
New York, New York 10016
Phone: 212-731-5076
?
mi
from
New York, NY
Click here to add this to my saved trials
?
mi
from
Papillion, NE
Click here to add this to my saved trials
3451 Walnut St
Philadelphia, Pennsylvania 19104
1 (215) 898-5000
Phone: 215-220-9713
Univ of Pennsylvania Penn has a long and proud tradition of intellectual rigor and pursuit...
?
mi
from
Philadelphia, PA
Click here to add this to my saved trials
PIttsburgh, Pennsylvania 15212
Phone: 412-359-8420
?
mi
from
PIttsburgh, PA
Click here to add this to my saved trials
Richmond, Virginia 23230
Phone: 804-287-3000
?
mi
from
Richmond, VA
Click here to add this to my saved trials
?
mi
from
Roanoke, VA
Click here to add this to my saved trials
Rochester, Minnesota 55905
Phone: 507-284-5280
?
mi
from
Rochester, MN
Click here to add this to my saved trials
Saint Petersburg, Florida 33705
Phone: 813-875-3950
?
mi
from
Saint Petersburg, FL
Click here to add this to my saved trials
San Antonio, Texas 78229
?
mi
from
San Antonio, TX
Click here to add this to my saved trials
San Diego, California 92123
?
mi
from
San Diego, CA
Click here to add this to my saved trials
Santa Barbara, California 93105
?
mi
from
Santa Barbara, CA
Click here to add this to my saved trials
Sioux Falls, South Dakota 65104
?
mi
from
Sioux Falls, SD
Click here to add this to my saved trials
Tualatin, Oregon 97062
?
mi
from
Tualatin, OR
Click here to add this to my saved trials