Early Onset and Familial Gastric Cancer Registry



Status:Active, not recruiting
Conditions:Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:11/10/2018
Start Date:December 2005
End Date:December 2019

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The purpose of this study is to establish a gastric cancer registry. A registry is a database
of information. With the registry, we can learn more about the genetic causes of gastric
cancer in order to develop better methods of early diagnosis, prevention, and treatment of
gastric cancers. As part of this study, you will be asked to join a registry of families who
are affected with various forms of gastric cancer. These registries are important because
they may help physicians better manage gastric cancer now and in the future. Participating in
the Early Onset and Familial Gastric Cancer Registry can also be educational for families,
since it will provide important information to patients, families, and physicians. All of
this will help to further our understanding of genetic causes of gastric cancer and
eventually, help determine better ways to diagnose, treat, and survey patients with gastric
cancer and people who may have a higher risk for gastric cancer.


Inclusion Criteria:

Patient/Relative Cohort:

Must meet one or more criteria below:

1. A person with a diagnosis of gastric or gastroesophageal junction (GEJ) adenocarcinoma
confirmed at the treating institution.

2. A person without gastric or GEJ adenocarcinoma who has or had a first degree relative
eligible for a High Risk Genetic sub-group (EOGC/FGC).

1. Early Onset Gastric Cancer - diagnosis of gastric cancer before the age of 50
without a family history of the disease.

2. Familial Gastric Cancer - having a family history of gastric cancer as defined as
one first degree relative or 2 second degree relatives.

3. A person without gastric or GEJ adenocarcinoma who has a personal family history of a
genetic mutation associated with the development of gastric or GEJ adenocarcinoma
(i.e. family history of CDH1 mutation).

II. Must be willing to provide a blood sample for germline DNA. These individuals will sign
the "Patient/Relative Consent". Following enrollment, we will assign individuals to the
appropriate High Genetic Risk or Low Genetic Risk groups based on the age of diagnosis and
their family history.

Subject Exclusion Criteria

Patients are ineligible for the study if they:

- Have any condition, which in the opinion of the primary MSK clinician or investigators
precludes their ability to provide informed consent.

- Relatives of patients that are not eligible for the High Genetic Risk Cohorts who are
less than 18 years of age are excluded.

- Relatives of patients eligible for the High Genetic Risk Cohorts who do not have a
proband available to join the study are excluded. (Unless there is a known CDH1
mutation in the family).
We found this trial at
10
sites
136 Mountainview Blvd
Basking Ridge, New Jersey 7920
(908) 542-3000
Phone: 212-639-8470
Memorial Sloan-Kettering Cancer Center - Basking Ridge At Memorial Sloan Kettering Basking Ridge, we offer...
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650 Commack Rd
Commack, New York 11725
(631) 623-4000
Phone: 212-639-8470
Memorial Sloan-Kettering Cancer Center at Commack Memorial Sloan Kettering Cancer Center - the world's oldest...
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500 Westchester Avenue
Harrison, New York 10604
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Harrison, NY
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Ile-Ife,
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Jamaica, New York 11432
Phone: 718-883-4031
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Jamaica, NY
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Los Angeles, California 90033
Phone: 323-865-3955
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Los Angeles, CA
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Middletown, New Jersey 07748
Phone: 212-639-8470
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1275 York Ave
New York, New York 10021
(212) 639-2000
Phone: 212-639-8470
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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New York, NY
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New York, New York 10065
Phone: 646-962-6200
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Rockville Centre, NY
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