A Study of XmAb®18087 in Subjects With NET and GIST



Status:Recruiting
Conditions:Cancer, Brain Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:12 - Any
Updated:3/27/2019
Start Date:January 22, 2018
End Date:June 2021
Contact:Barbara Hickingbottom, MD
Email:bhickingbottom@xencor.com
Phone:858-480-3413

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A Phase 1 Multiple Dose Study to Evaluate the Safety and Tolerability of XmAb®18087 in Subjects With Advanced Neuroendocrine and Gastrointestinal Stromal Tumors (DUET-1)

This is a Phase 1, multiple dose, ascending dose escalation study; to define a MTD/RD and
regimen consisting of a first "priming" dose and escalated subsequent doses of XmAb18087; to
describe safety and tolerability; to assess PK and immunogenicity; and to preliminarily
assess anti-tumor activity of XmAb18087 in subjects with advanced NET or GIST.

The study will enroll dosing cohorts to establish a MTD/RD and regimen in subjects with
advanced NET or GIST, then enroll additional subjects into separate NET and GIST expansion
cohorts to collect additional data on safety and potential efficacy of XmAb18087.


Inclusion Criteria:

- Histologically or cytologically confirmed well differentiated low or intermediate
grade (World Health Organization [WHO] Grade 1 or 2) NET of pancreatic,
gastrointestinal, lung, or undetermined origin that is locally advanced or metastatic
and has progressed within the past 12 months

- Histologically confirmed GIST that is locally advanced or metastatic

- NET and GIST tumors must be unresectable

- NET subjects must have progressed on or been ineligible for treatment with
somatostatin analogues (SSA) and at least one other FDA-approved targeted therapy
(everolimus or sunitinib).

- GIST subjects must have previously received all FDA-approved therapies (imatinib
mesylate, sunitinib malate, and regorafenib) for which they are eligible

- Must have disease measurable by RECIST 1.1 criteria using either computed tomography
(CT) or magnetic resonance imaging (MRI) scan

- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1

Exclusion Criteria:

- Diagnosis of high-grade (WHO Grade 3) or poorly differentiated NET; high-grade
neuroendocrine carcinoma; large cell neuroendocrine carcinoma, small cell carcinoma,
or mixed small and large cell carcinoma.

- Subjects currently receiving anti-cancer therapies (other than SSAs, which may
continue).

- Subjects who have received anti-cancer therapies within 2 weeks of the start of study
drug (including chemotherapy, radiation therapy, immunotherapy, etc.).

- Must not be experiencing a Grade 3 or 4 toxicity from previous anti-cancer treatment

- Must not be receiving other anti-cancer therapies (except somatostatin analogues,
which may be allowed)

- Must not have poorly controlled diabetes mellitus, known central nervous system
involvement by malignant disease or insufficient bone marrow, renal, or hepatic
function
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201 Dowman Dr
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