Spectroscopy With Surface Coils and Decoupling
| Status: | Completed |
|---|---|
| Conditions: | Breast Cancer, Lung Cancer, Prostate Cancer, Colorectal Cancer, Ovarian Cancer, Liver Cancer, Cancer, Brain Cancer, Lymphoma, Pancreatic Cancer, Thyroid Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | February 1997 |
| End Date: | February 2014 |
The purpose of this study is to obtain chemical information from part of your body without a
biopsy. This is done using a technique called magnetic resonance spectroscopy (MRS) which is
similar to magnetic resonance imaging (MRI) except that signals are detected from the
chemicals (spectroscopy) naturally present in your body using radio waves. To receive this
information from your body, small loops of wire (surface coils), placed near the tissue of
interest, may be used to more effectively detect signals that come from the chemicals in
your body. The investigators may use a second radio channel simultaneously, which will allow
us to obtain greater chemical information (decoupling). The results may also help us to
understand how this study can be used to help other patients with your condition.
biopsy. This is done using a technique called magnetic resonance spectroscopy (MRS) which is
similar to magnetic resonance imaging (MRI) except that signals are detected from the
chemicals (spectroscopy) naturally present in your body using radio waves. To receive this
information from your body, small loops of wire (surface coils), placed near the tissue of
interest, may be used to more effectively detect signals that come from the chemicals in
your body. The investigators may use a second radio channel simultaneously, which will allow
us to obtain greater chemical information (decoupling). The results may also help us to
understand how this study can be used to help other patients with your condition.
The investigators propose to use 1H spectroscopy or 1H decoupled 31P NMR spectroscopy to
obtain biochemical information about tumor metabolism in patients, both before and after
antineoplastic therapy. In healthy volunteers, normal tissue metabolism will also be
studied. It is hypothesized that metabolic information may be of prognostic significance, or
may be useful for timing of therapy.
obtain biochemical information about tumor metabolism in patients, both before and after
antineoplastic therapy. In healthy volunteers, normal tissue metabolism will also be
studied. It is hypothesized that metabolic information may be of prognostic significance, or
may be useful for timing of therapy.
Inclusion Criteria:
- Patients must have suspected or documented neoplastic disease, strongly suspected or
established by physical examination, history or conventional histologic biochemical
or imaging techniques, or have surgical or aspiration biopsy that will be used to
establish a diagnosis
- Patients with obstructive jaundice, both from malignant and non-malignant disease,
will be considered for the study
- Patients/volunteers must be clinically stable and not require cardiovascular
monitoring
- Patients must be 6 years of age or older and be able to cooperate for an
approximately 60 minute examination
- Volunteers must be 18 years of age or older
Exclusion Criteria:
- Inability to cooperate for an MR exam
- Contraindication to MR: Pacemaker, Aneurysmal clips Any ferrous metallic implants
which could be deflected by the magnet, Metal implants in field of view, Pregnant
women, OR Age and mental status wherein he/she is unable to cooperate for MR study
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Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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