Treatment of Orthostatic Hypotension
| Status: | Enrolling by invitation |
|---|---|
| Conditions: | Cardiology, Neurology |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Neurology |
| Healthy: | No |
| Age Range: | 18 - 70 |
| Updated: | 1/12/2019 |
| Start Date: | January 2004 |
| End Date: | December 2020 |
Treatment of Hypotensive Patients Having a Unique Pattern of Autonomic Symptoms
The purpose of this study is to try different medications in patients with low blood pressure
and other problems with their involuntary (autonomic) nervous system. The pharmacological
trials in this study will perhaps lead to more effective treatment. This study consists of
single dose trials, dose selection trials, 5-day trials and chronic (approximately 2 months)
trials.
and other problems with their involuntary (autonomic) nervous system. The pharmacological
trials in this study will perhaps lead to more effective treatment. This study consists of
single dose trials, dose selection trials, 5-day trials and chronic (approximately 2 months)
trials.
We see many patients at the Autonomic Dysfunction Center who can be given a fairly definitive
diagnosis, e.g., Orthostatic Intolerance, Pure Autonomic Failure, Multiple System Atrophy,
and Baroreflex Failure. However, some patients present with a unique constellation of
symptoms of autonomic dysfunction so that they do not fit into a diagnostic category. We
hypothesize that a genetic cause exists in some of these patients. We further propose that
our comprehensive evaluation of these patients will provide us with information on the
pathophysiology of their condition and assist us in optimizing their treatment.
diagnosis, e.g., Orthostatic Intolerance, Pure Autonomic Failure, Multiple System Atrophy,
and Baroreflex Failure. However, some patients present with a unique constellation of
symptoms of autonomic dysfunction so that they do not fit into a diagnostic category. We
hypothesize that a genetic cause exists in some of these patients. We further propose that
our comprehensive evaluation of these patients will provide us with information on the
pathophysiology of their condition and assist us in optimizing their treatment.
Inclusion Criteria:
- patients with severe orthostatic hypotension and other autonomic symptoms who do not
meet criteria for one of our standard diagnoses
- non-smokers
- drug-free
- able to give informed consent
- free of pulmonary, renal, hematopoietic, hepatic and cardiac disease
Exclusion Criteria:
- medications affecting the autonomic nervous system
- any chronic illness (cardiac, pulmonary, endocrine, gastrointestinal, rheumatologic)
- anemia (Hct < 30)
- women of childbearing age who are pregnant or nursing
- smokers
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