VCRC Longitudinal Protocol for Aortitis



Status:Recruiting
Healthy:No
Age Range:5 - Any
Updated:3/27/2019
Start Date:December 4, 2017
End Date:December 2020
Contact:Carol McAlear, MA
Email:cmcalear@upenn.edu
Phone:78132145677

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The term 'aortitis' refers to inflammation of the aorta. Aortitis is known to occur in a
variety of vasculitides and connective tissue diseases, such as giant cell arteritis (GCA),
Takayasu arteritis (TAK), rheumatoid arthritis, and spondyloarthropathies, among others. This
study will establish a longitudinal cohort for these diseases.

This study will develop a longitudinal cohort of patients with different types of aortitis to
systematically study the natural history, optimal treatments, and outcomes in this group of
diseases. This will provide a resource for future studies and for identification of new
biomarkers of aortitis for purposes of diagnosis, disease activity measurement, disease
damage assessment, determination of disease states, and evaluation of treatment response.

Inclusion Criteria:

Subjects will be included if they meet one of the following criteria:

1. Previous or current microscopic evidence of aortitis (active or healed) on surgical
specimen obtained during aortic resection

2. Previous or current radiographic aortitis that could include circumferential aortic
wall thickening of at least 3mm on CT or MRI or increased PET FDG uptake in the aorta
at values equal to or greater than the liver, in absence of an alternative explanation
for the radiographic findings.

Exclusion

1. Subjects already enrolled in one of the other VCRC longitudinal cohorts: 5502, 5503,
5504, 5505, and 5506.

2. Inability of participants (or their guardians in the case of children) to give
informed consent and to sign the consent form.
We found this trial at
8
sites
75 Francis street
Boston, Massachusetts 02115
(617) 732-5500
Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...
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4200 Fifth Ave
Pittsburgh, Pennsylvania 15260
(412) 624-4141
University of Pittsburgh The University of Pittsburgh is a state-related research university, founded as the...
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201 Presidents Circle
Salt Lake City, Utah 84108
801) 581-7200
University of Utah Research is a major component in the life of the U benefiting...
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Salt Lake City, UT
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One Silber Way
Boston, Massachusetts 02215
(617) 353-2000
Boston University Boston University is no small operation . With over 33,000 undergraduate and graduate...
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Boston, MA
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2049 E 100th St
Cleveland, Ohio 44106
(216) 444-2200
Cleveland Clinic Foundation The Cleveland Clinic (formally known as The Cleveland Clinic Foundation) is a...
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Cleveland, OH
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3451 Walnut St
Philadelphia, Pennsylvania 19104
1 (215) 898-5000
Univ of Pennsylvania Penn has a long and proud tradition of intellectual rigor and pursuit...
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Philadelphia, PA
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Rochester, Minnesota 55905
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Rochester, MN
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Vancouver,
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