Do Treatments for Smoking Cessation Affect Alcohol Drinking?

Inclusion Criteria:

- 21 years old or older

- Able to read and write in English

- Smokers, non-daily smokers, and non-smokers

- Heavy Drinkers and/or meet criteria for alcohol use disorders

Exclusion Criteria:

- Any significant current medical or psychiatric conditions that would contraindicate
the consumption of alcohol

- Significant hepatocellular injury

- Positive test result at intake appointments on urine drug screens conducted for
opiates, cocaine, or benzodiazepines

- Women who are pregnant or nursing

- Suicidal, homicidal, or evidence of severe mental illness

- Prescription of any psychotropic drug in the 30 days prior to study enrollment

- Blood donation within the past 8 weeks

- Individuals who are seeking treatment for drinking or smoking or who have attempted to
quit drinking or smoking within the past 3 months

- Specific exclusions for administration of bupropion not specified above including:
having taken monoamine inhibitors in the past six weeks; history of anorexia or
bulimia; previous hypersensitivity to bupropion; history of alcohol or drug dependence
in the past year; history of seizure disorder of any etiology

- Known allergy to varenicline or taking H2blockers

- Participation within the past 8 weeks in other studies that involve additive blood
sampling and/or interventional measures that would be considered excessive in
combination with the current study

- Subjects likely to exhibit clinically significant alcohol withdrawal during the study