Dual-Energy CT on Plan Quality, Dose-delivery Accuracy, and Simulated Patient Outcomes for Locally Advanced Lung and Brain Tumor Patients Treated With Proton Therapy
| Status: | Recruiting |
|---|---|
| Conditions: | Lung Cancer, Cancer, Cancer, Brain Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 2/10/2019 |
| Start Date: | June 1, 2018 |
| End Date: | June 1, 2022 |
| Contact: | Jeffrey Bradley, M.D. |
| Email: | jbradley@wustl.edu |
| Phone: | (314) 747-1786 |
A Virtual Clinical Trial to Assess the Impact of Dual-Energy CT on Plan Quality, Dose-delivery Accuracy, and Simulated Patient Outcomes for Locally Advanced Lung and Brain Tumor Patients Treated With Proton Therapy
The aim of this protocol is to refine the accuracy of proton beam therapy (PT) by the use of
dual energy computed tomography (DECT), in conjunction with novel iterative image
reconstruction algorithms, to more precisely determine the tissue properties through which
the proton beam path travels.
dual energy computed tomography (DECT), in conjunction with novel iterative image
reconstruction algorithms, to more precisely determine the tissue properties through which
the proton beam path travels.
Eligibility Criteria:
Inclusion Criteria:
- Diagnosis of histologically proven node-positive lung cancer (n=20) OR base of skull
or brain tumor (n=20).
- Tumor(s) must be located near air cavities.
- At least 18 years of age.
- Karnofsky performance score of at least 80.
- Planning to undergo proton beam radiation therapy as part of the clinical management
of the diagnosed cancer.
- Able to understand and willing to sign an IRB-approved written informed consent
document.
Exclusion Criteria:
- Implanted metallic objects.
- IV or oral contrast medium within the week prior to enrollment.
- Pregnant.
We found this trial at
1
site
660 S Euclid Ave
Saint Louis, Missouri 63110
Saint Louis, Missouri 63110
(314) 362-5000
Principal Investigator: Jeffrey Bradley, M.D.
Phone: 314-747-1786
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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