An Investigational Immuno-Therapy Study of Experimental Medication BMS-986253 Given in Combination With Nivolumab in Patients With Advanced Cancers



Status:Recruiting
Conditions:Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:4/5/2019
Start Date:January 31, 2018
End Date:November 26, 2023
Contact:Recruiting sites have contact information. Please contact the sites directly. If there is no contact information,
Email:Clinical.Trials@bms.com
Phone:please email:

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A Phase 1/2a Study of BMS-986253 in Combination With Nivolumab in Advanced Cancers

The purpose of this study is to investigate experimental medication BMS-986253 in combination
with Nivolumab in patients with advanced cancers.


For more information regarding Bristol-Myers Squibb Clinical Trial participation, please
visit www.BMSStudyConnect.com

Inclusion Criteria:

- Histologic or cytologic confirmation of a solid tumor that is advanced (metastatic,
recurrent and/or unresectable) with measurable disease per RECIST v1.1

- At least 1 lesion accessible for biopsy

- Eastern Cooperative Oncology Group Performance Status of 0 or 1

Exclusion Criteria:

- Participants with CNS metastases as the only site of active disease (Participants with
controlled brain metastases; however, will be allowed to enroll)

- Participants with active, known or suspected autoimmune disease

- Participants with conditions requiring systemic treatment with either corticosteroids
(> 10mg prednisone equivalents) or other immunosuppressive medications within 14 days
of study treatment administration

- Participants with a known history of testing positive for Human Immunodeficiency Virus
(HIV) or known Acquired Immunodeficiency Syndrome (AIDS)

- Cytotoxic agents, unless at least 4 weeks have elapsed from last dose of prior
anti-cancer therapy and initiation of study therapy

Other protocol defined inclusion/exclusion criteria could apply
We found this trial at
24
sites
9280 W. Sunset Road Suite 100
Las Vegas, Nevada 89148
702.952.1251
Comprehensive Cancer Centers of Nevada Comprehensive Cancer Centers of Nevada (CCCN) is the award-winning multidisciplinary...
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Las Vegas, NV
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1500 E Medical Center Dr
Ann Arbor, Michigan 48109
(734) 936-4000
University of Michigan Health System The University of Michigan is home to one of the...
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Ann Arbor, MI
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Austin, Texas 78731
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Austin, TX
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99-101 Belliardstraat
Bruxelles, 1040
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Bruxelles,
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Dallas, TX
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Denver, Colorado 80218
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Denver, CO
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Eugene, OR
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8503 Arlington Blvd., Ste. 400
Fairfax, Virginia 22031
(703) 280-5390
Virginia Cancer Specialists, PC Now the world's most advanced cancer treatment capabilities can be found...
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Fairfax, VA
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Fort Worth, Texas 76104
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Fort Worth, TX
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Greenville, South Carolina 29615
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Greenville, SC
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92 2nd St
Hackensack, New Jersey 07601
(201) 996-5900
John Theurer Cancer Center at the Hackensack University Medical Center The mission of the John...
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Hackensack, NJ
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Houston, Texas 77030
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Houston, TX
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Lutherville, MD
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Miami Beach, Florida 33140
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Miami Beach, FL
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New Brunswick, New Jersey 08903
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New Brunswick, NJ
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New York, NY
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1428 Madison Ave
New York, New York 10029
(212) 241-6500
Icahn School of Medicine at Mount Sinai Icahn School of Medicine at Mount Sinai is...
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New York, NY
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5900 Lake Wright Dr
Norfolk, Virginia 23502
(757) 466-8683
Virginia Oncology Associates Virginia Oncology Associates is an oncology and hematology practice of physicians, specializing...
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Norfolk, VA
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Oklahoma City, Oklahoma 73104
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Oklahoma City, OK
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Philadelphia, Pennsylvania 19102
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Philadelphia, PA
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Pittsburgh, Pennsylvania 15232
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Rockville, Maryland 20850
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Rockville, MD
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San Antonio, TX
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Tyler, Texas 75702
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