Can Transcranial Direct Current Stimulation Improve Ambulation and Fatigue Resistance in People With MS?
| Status: | Completed |
|---|---|
| Conditions: | Neurology, Multiple Sclerosis |
| Therapuetic Areas: | Neurology, Other |
| Healthy: | No |
| Age Range: | 30 - 60 |
| Updated: | 7/19/2018 |
| Start Date: | November 2016 |
| End Date: | June 2018 |
In this project the investigators will be using non-invasive brain stimulation on people with
multiple sclerosis (PwMS) to improve leg muscle function. Two groups of participants will be
recruited. One group will perform strength testing with and without the brain stimulation.
After completing the strength testing the participants will walk for six minutes to see if
any increases in strength translate into improve mobility. The second group of participants
will perform a fatigue task, pulling against a wire at a low level of force, with and without
the brain stimulation. This type of brain stimulation has been shown to transiently improve
strength and fatigue measures in other populations, e.g. aged, Parkinson's, and improve
cognitive abilities in people with multiple sclerosis. It is the investigator's hope that the
increases in performance seen in other patient groups will also occur in people with multiple
sclerosis. Future investigations will look to apply the non-invasive brain stimulation
technique during physical rehabilitation to improve short and long term outcomes related to
physical function.
multiple sclerosis (PwMS) to improve leg muscle function. Two groups of participants will be
recruited. One group will perform strength testing with and without the brain stimulation.
After completing the strength testing the participants will walk for six minutes to see if
any increases in strength translate into improve mobility. The second group of participants
will perform a fatigue task, pulling against a wire at a low level of force, with and without
the brain stimulation. This type of brain stimulation has been shown to transiently improve
strength and fatigue measures in other populations, e.g. aged, Parkinson's, and improve
cognitive abilities in people with multiple sclerosis. It is the investigator's hope that the
increases in performance seen in other patient groups will also occur in people with multiple
sclerosis. Future investigations will look to apply the non-invasive brain stimulation
technique during physical rehabilitation to improve short and long term outcomes related to
physical function.
Inclusion Criteria:
- Medically diagnosed with MS
- Moderate disability (Patient Determined Disease Steps score 2-6)
- Self-reported differences in function between the legs (2-5 on a 1-5 scale)
- People with MS with physician clearance
Exclusion Criteria:
- A relapse of disease symptoms in the last 60 days
- A condition unrelated to MS that would exacerbate fatigue, such as anemia,
hypothyroidism, shiftwork-related fatigue, B12 deficiency, major sleep disorder, or
major depressive disorder
- Medical diagnosis or condition that makes participating in exercise training
dangerous, such as major renal, pulmonary, hepatic, cardiac, gastrointestinal, HIV,
cancer (other than treated basal cell cancer), other neurological disorders, or
pregnancy
- History of heart attack or current diagnosis of cardiovascular disease
- History of seizure disorders (or on medications known to lower seizure threshold),
hydrocephalus (buildup of fluid in the brain), or diabetes
- Alcohol dependence or abuse (>2 drinks/day), or present history (last six months) of
drug abuse
- History of significant traumatic brain injury or hydrocephalus
- Pregnancy
- Recent hospitalization (within the last 3 months) or enforced bed rest/sedentary
state.
- Presence of metal is present or implanted device or metal object that is not safe for
TMS.
We found this trial at
1
site
951 West Plum Street
Fort Collins, Colorado 80523
Fort Collins, Colorado 80523
Phone: 970-491-8655
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