Antibacterial-coated Sutures at Time of Cesarean



Status:Recruiting
Conditions:Infectious Disease, Hospital
Therapuetic Areas:Immunology / Infectious Diseases, Other
Healthy:No
Age Range:18 - 50
Updated:1/23/2019
Start Date:January 9, 2018
End Date:January 2021
Contact:Violetta Lozovyy, M.D.
Email:vilozovy@utmb.edu
Phone:409-772-1571

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Abdominal closure with antibacterial-coated sutures has been shown to reduce wound infections
after a number of surgical procedures, but none of the previous trials included cesarean
delivery. Our objective is to determine whether use of antibacterial-coated sutures reduces
surgical site infection (SSI) after cesarean delivery.

A review of 18 studies demonstrated a significant benefit of antimicrobial coated sutures in
reducing SSI (RCTs: OR 0.72; 95% CI 0.59-0.88; observational studies: OR 0.58; 95% CI
0.40-0.83). As there are no clinical trials focusing on cesarean delivery, and because the
risk factors and pathogenesis for post-cesarean SSI may not mirror other procedures, further
data is needed before generalizing the WHO recommendations to cesarean procedures.

Inclusion Criteria:

- 18-50 years of age.

- Women ≥ 24 weeks' viable gestation.

- To undergo cesarean delivery.

Exclusion Criteria:

- Patient unwilling or unable to provide consent.

- No prenatal care or a non-resident patient who is unlikely to be followed-up after
delivery.

- Immunosuppressed patients: i.e., taking systemic immunosuppressant or steroids (e.g.
transplant patients; not including steroids for lung maturity), HIV with CD4<200, or
other.

- Decision to use other than suture closure (e.g. secondary wound closure, mesh
closure).

- Skin infection.

- Coagulopathy.

- High likelihood of additional surgical procedure beyond cesarean (e.g. scheduled
hysterectomy, bowel or adnexal surgery).

- Allergy to Triclosan.

- Incarcerated individuals.
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Galveston, Texas
Phone: 409-772-1571
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