Study of Low Carbohydrate Enteral Nutrition in Patients With Bacterial Septic Shock

Therapuetic Areas:Other
Age Range:18 - 65
Start Date:January 8, 2018
End Date:June 2019
Contact:Andrew Wang, MD PhD

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Pilot Study of Low-Carbohydrate Enteral Nutrition in Patients With Bacterial Septic Shock

This pilot study aims to test the tolerability of low-carbohydrate enteral nutrition in
patients with bacterial septic shock.

This study seeks to assess the tolerability of utilizing low-carbohydrate nutrition in
patients admitted to the MICU with bacterial septic shock. Low carbohydrate feeds have been
used before in the critical care setting and were well-tolerated.

Inclusion Criteria:

1. Patients aged 18-65 admitted to the MICU with a diagnosis of severe sepsis or septic

2. Patients with 35 > BMI > 18.5

3. Patients with serum pro-calcitonin > 1 ng/mL in the first 24 hours of hospitalization

Exclusion Criteria:

1. Patients with chronic kidney disease as defined by glomerular filtration rate < 60 for
> 6 months

2. Patients with chronic liver disease as defined by radiographic or tissue evidence of
cirrhosis or persistently abnormal liver function tests for > 6 months

3. Patients with current malignancies

4. Patients with autoimmune disease on current immunotherapy

5. Patients on corticosteroids at doses of prednisone or prednisone-equivalents > 5 mg
for > 6 months

6. Patients with weight-reduction surgeries

7. Patients with positive viral studies in the first 24 hours of admission
We found this trial at
20 York St, N20 York St,
New Haven, Connecticut 06520
(203) 688-4242
Yale-New Haven Hospital Relying on the skill and expertise of more than 4,500 university and...
New Haven, CT
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