Sleep Apnea and Hypertrophic Cardiomyopathy (HCM)
| Status: | Recruiting |
|---|---|
| Conditions: | High Cholesterol, Insomnia Sleep Studies, Cardiology, Orthopedic |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Psychiatry / Psychology, Orthopedics / Podiatry |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 3/24/2019 |
| Start Date: | November 13, 2017 |
| End Date: | June 2025 |
| Contact: | CPL Lab |
| Email: | CPLHCM@mayo.edu |
| Phone: | 507-293-2762 |
A Prevalence and Incidence Study Investigating the Burden of Atrial and Ventricular Arrhythmias in Patients With Hypertrophic Cardiomyopathy and Sleep Apnea.
The investigators are trying to find out how common sleep apnea is in hypertrophic
cardiomyopathy. The purpose of this study is to see if sleep apnea is common in hypertrophic
cardiomyopathy and if its presence is associated with changes in the functioning of the body.
The investigators want to determine if sleep apnea is associated with electrical disorders of
the heart in patients with hypertrophic cardiomyopathy.
cardiomyopathy. The purpose of this study is to see if sleep apnea is common in hypertrophic
cardiomyopathy and if its presence is associated with changes in the functioning of the body.
The investigators want to determine if sleep apnea is associated with electrical disorders of
the heart in patients with hypertrophic cardiomyopathy.
Participants will be healthy volunteers or subjects with the diagnosis of hypertrophic
cardiomyopathy (HCM). All patients will a undergo a one time; medical history, physical
examination, questionnaires, sleep observation in hospital, blood and urine samples,
ultrasound scan of the heart, paced breathing test, ultrasound of brachial artery in the arm,
MRI of the heart & 48 hour ECG Holter monitoring. Comparison between the normal volunteers
and subjects with HCM will be made.
cardiomyopathy (HCM). All patients will a undergo a one time; medical history, physical
examination, questionnaires, sleep observation in hospital, blood and urine samples,
ultrasound scan of the heart, paced breathing test, ultrasound of brachial artery in the arm,
MRI of the heart & 48 hour ECG Holter monitoring. Comparison between the normal volunteers
and subjects with HCM will be made.
Inclusion criteria:
- Able to consent
- Non-pregnant
Exclusion criteria:
- Decompensated Heart failure (symptoms and N-terminal pro b-type natriuretic peptide
(NT-proBNP) >332 ng/L in the absence of renal failure or competing cause)
- Prior alcohol septal ablation
- Surgical myectomy
- Prosthetic valves
- Current smokers or recently quit (<6 months)
- Chronic obstructive pulmonary disease (COPD) (FEV1/Forced vital capacity (FVC) <0.70;
FEV1 <80%)
- Known autonomic dysfunction
- (Fully) Treated sleep apnea (mandibular device, CPAP)
- Vulnerable study population
- Prior catheter ablation for atrial fibrillation
We found this trial at
1
site
Rochester, Minnesota 55905
Principal Investigator: Virend K Somers, MD, PhD
Phone: 507-293-2762
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