Therapeutic Oxygen for Gastrointestinal Atony (TOGA)

TOGA involves the provision of a 6- hour treatment with 100% oxygen via non breather mask to
hospitalized patients with ileus, small bowel obstruction and/or colonic pseudo-obstruction
will be a useful supplemental therapy, decreasing the diameter of the intestinal lumen and
enhancing resolution of ileus/pseudo-obstruction

Inclusion Criteria:

- patient or health proxy has been adequately informed of risks and benefits and agrees
to his/her participation in the study.

- patient is a hospitalized inpatient diagnosed with ileus, bowel obstruction or colonic
pseudo-obstruction [clinician interpretation or small bowel diameter ≥3.5 cm, cecal
diameter ≥ 9 cm, sigmoid colon diameter ≥ 6 cm].

- patient is clinically and hemodynamically stable

- patient does not require supplemental oxygen greater than 2 liters per minute via
nasal cannula

- patient does not have any respiratory contraindications to 100% oxygen

- failure to respond to non-surgical/non-endoscopic therapy for at least 24 hours,
therapy at discretion of treating physician [to eliminate patients with trivial ileus
not requiring advanced intervention]

Exclusion Criteria:

- patient is not expected to survive in the short term.

- patient is a pregnant or lactating woman.

- patient presents with severe or unstable psychiatric disorders.

- patient is participating in concomitant research studies that would interfere with
this study.

- patient is an alcohol or drug abuser.

- respirator support required.

- unable to tolerate 100% oxygen for respiratory reasons or any other reasons.

- perforation of the viscus.

- inability to obtain informed consent.

- hypoxemia, as in room air oxygen saturation less than 90%.