Telmisartan (Micardis) and Ramipril (Altace) - Factorial Design Study for the Treatment of Hypertension



Status:Completed
Conditions:High Blood Pressure (Hypertension)
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - Any
Updated:12/30/2017
Start Date:April 2006

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Trial Summary
Trial Overview
Inclusion Criteria

A Randomized, Double-blind, Double-dummy, Placebo-controlled, 3x4 Factorial Design Trial to Evaluate Telmisartan 20 and 80 mg Tablets in Combination With Ramipril 1.25, 10, and 20 mg Capsules After Eight Weeks of Treatment in Patients With Stage I or II Hypertension, With an ABPM Sub-study

To identify dose combinations of telmisartan and ramipril that are more effective in reducing
diastolic blood pressure than each of the respective monotherapies in patients with Stage I
or II hypertension.


Inclusion Criteria:

- Male and female patients >=18 years of age with Stage I or II hypertension defined as:

- a mean seated cuff diastolic blood pressure >=95 and <=119 mmHg Main

Exclusion Criteria:

- Pregnant

- breast-feeding

- unwilling to use birth control during the study

- secondary hypertension

- SBP>=180 mmHg

- DBP>=120 mmHg

- severe renal dysfunction

- hepatic insufficiency

- stroke within the last 6 months

- myocardial infarction, cardiac surgery, percutaneous transluminal coronary
angioplasty, unstable angina or coronary artery bypass graft within the past three
months

- unstable or uncontrolled diabetes

- history of angioedema of either of the study drugs, and hypersensitivity to the study
drugs.
We found this trial at
62
sites
205.452.01184 Boehringer Ingelheim Investigational Site
Jupiter, Florida
915
mi
from 43215
Jupiter, FL
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Boehringer Ingelheim Investigational Site
Albuquerque, New Mexico
1333
mi
from 43215
Albuquerque, NM
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205.452.01364 Boehringer Ingelheim Investigational Site
Auburn, Maine
714
mi
from 43215
Auburn, ME
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1245.20.10128 Boehringer Ingelheim Investigational Site
Avon, Indiana
179
mi
from 43215
Avon, IN
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1245.28.10033 Boehringer Ingelheim Investigational Site
Blue Ridge, Georgia
360
mi
from 43215
Blue Ridge, GA
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1237.5.01015 Boehringer Ingelheim Investigational Site
Boulder, Colorado
1174
mi
from 43215
Boulder, CO
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502.476.067 Boehringer Ingelheim Investigational Site
Buena Park, California
1964
mi
from 43215
Buena Park, CA
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1200.75.54005 Boehringer Ingelheim Investigational Site
Buenos Aires,
5386
mi
from 43215
Buenos Aires,
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1236.1.555 Boehringer Ingelheim Investigational Site
Cadillac, Michigan 49601
320
mi
from 43215
Cadillac, MI
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1218.74.01105 Boehringer Ingelheim Investigational Site
Carrollton, Texas
907
mi
from 43215
Carrollton, TX
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Boehringer Ingelheim Investigational Site
Cincinnati, Ohio
98
mi
from 43215
Cincinnati, OH
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Boehringer Ingelheim Investigational Site
Columbus, Ohio
1
mi
from 43215
Columbus, OH
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1264.3.01031 Boehringer Ingelheim Investigational Site
Concord, California
2082
mi
from 43215
Concord, CA
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205.452.01189 Boehringer Ingelheim Investigational Site
Corvallis, Oregon
2060
mi
from 43215
Corvallis, OR
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1236.1.534 Boehringer Ingelheim Investigational Site
Cumberland, Rhode Island
619
mi
from 43215
Cumberland, RI
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1268.17.01045 Boehringer Ingelheim Investigational Site
Deland, Florida
761
mi
from 43215
Deland, FL
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205.452.01038 Boehringer Ingelheim Investigational Site
Encinitas, California
1949
mi
from 43215
Encinitas, CA
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205.452.01323 Boehringer Ingelheim Investigational Site
Erie, Pennsylvania
213
mi
from 43215
Erie, PA
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205.452.01341 Boehringer Ingelheim Investigational Site
Eugene, Oregon
2055
mi
from 43215
Eugene, OR
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1236.1.541 Boehringer Ingelheim Investigational Site
Excelsior Springs, Missouri 64024
597
mi
from 43215
Excelsior Springs, MO
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1220.48.0043 Boehringer Ingelheim Investigational Site
Falls Church, Virginia
320
mi
from 43215
Falls Church, VA
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1311.3.10103 Boehringer Ingelheim Investigational Site
Farmington, Connecticut
548
mi
from 43215
Farmington, CT
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1301.1.5727 Boehringer Ingelheim Investigational Site
Glendale, Arizona
1665
mi
from 43215
Glendale, AZ
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1236.1.505 Ledeeach Family Medicine
658 Harleysville Pike
Harleysville, Pennsylvania 19438
402
mi
from 43215
Harleysville, PA
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205.452.01269 Boehringer Ingelheim Investigational Site
Haverhill, Massachusetts
648
mi
from 43215
Haverhill, MA
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205.452.01209 Boehringer Ingelheim Investigational Site
Hialeah, Florida
989
mi
from 43215
Hialeah, FL
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Boehringer Ingelheim Investigational Site
Houston, Texas
991
mi
from 43215
Houston, TX
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1236.1.546 River Cities Cardiology Research Inst of Middle America
41 Quartermaster Court
Jeffersonville, Indiana 47130
184
mi
from 43215
Jeffersonville, IN
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1245.25.10156 Boehringer Ingelheim Investigational Site
Kettering, Ohio
63
mi
from 43215
Kettering, OH
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1160.128.1054 Boehringer Ingelheim Investigational Site
Largo, Florida
832
mi
from 43215
Largo, FL
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1218.61.01052 Boehringer Ingelheim Investigational Site
Las Vegas, Nevada
1756
mi
from 43215
Las Vegas, NV
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1199.14.1181 Boehringer Ingelheim Investigational Site
Long Beach, California
1977
mi
from 43215
Long Beach, CA
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Boehringer Ingelheim Investigational Site
Los Angeles, California
1972
mi
from 43215
Los Angeles, CA
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1199.14.1186 Boehringer Ingelheim Investigational Site
Madison, Wisconsin
392
mi
from 43215
Madison, WI
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1245.28.10020 Boehringer Ingelheim Investigational Site
Medford, Oregon
2060
mi
from 43215
Medford, OR
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502.476.106 Boehringer Ingelheim Investigational Site
Menomonee Falls, Wisconsin
344
mi
from 43215
Menomonee Falls, WI
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1218.61.01040 Boehringer Ingelheim Investigational Site
Meridian, Idaho
1725
mi
from 43215
Meridian, ID
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1236.1.503 Anchor Research Center
15205 Collier Boulevard
Naples, Florida 34119
949
mi
from 43215
Naples, FL
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1199.14.1057 Boehringer Ingelheim Investigational Site
New Port Richey, Florida
809
mi
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New Port Richey, FL
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1245.23.10157 Boehringer Ingelheim Investigational Site
Newton, Kansas
779
mi
from 43215
Newton, KS
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1222.29.11004 Boehringer Ingelheim Investigational Site
North Dartmouth, Massachusetts
639
mi
from 43215
North Dartmouth, MA
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1218.64.10018 Boehringer Ingelheim Investigational Site
Pembroke Pines, Florida
977
mi
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Pembroke Pines, FL
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1200.43.00106 Boehringer Ingelheim Investigational Site
Peoria, Illinois
349
mi
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Peoria, IL
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Boehringer Ingelheim Investigational Site
Portland, Oregon
2026
mi
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Portland, OR
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1236.1.566 Boehringer Ingelheim Investigational Site
Richmond, Kentucky
167
mi
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Richmond, KY
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1218.83.11014 Boehringer Ingelheim Investigational Site
Roseville, California
2029
mi
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Roseville, CA
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205.452.01001 Boehringer Ingelheim Investigational Site
Salt Lake City, Utah
1513
mi
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Salt Lake City, UT
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Boehringer Ingelheim Investigational Site
San Antonio, Texas
1138
mi
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San Antonio, TX
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502.476.097 Boehringer Ingelheim Investigational Site
Sandy, Utah
?
mi
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Sandy, UT
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Boehringer Ingelheim Investigational Site
Spartanburg, South Carolina
351
mi
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Spartanburg, SC
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9.197.001 Boehringer Ingelheim Investigational Site
Tempe, Arizona
1656
mi
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Tempe, AZ
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1236.1.570 Boehringer Ingelheim Investigational Site
The Colony, Texas
903
mi
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The Colony, TX
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1245.25.10162 Boehringer Ingelheim Investigational Site
Tipton, Pennsylvania
253
mi
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Tipton, PA
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1236.1.525 Physicians Research Center, LLC, Toms River
9 Mule Road
Toms River, New Jersey 08755
464
mi
from 43215
Toms River, NJ
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205.452.01221 Boehringer Ingelheim Investigational Site
Troy, Michigan
179
mi
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Troy, MI
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1268.17.01043 Boehringer Ingelheim Investigational Site
Tucson, Arizona
1641
mi
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Tucson, AZ
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205.452.01307 Boehringer Ingelheim Investigational Site
Tulsa, Oklahoma
752
mi
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Tulsa, OK
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205.452.01362 Boehringer Ingelheim Investigational Site
Tustin, California
1957
mi
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Tustin, CA
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1245.25.10206 Boehringer Ingelheim Investigational Site
Valparaiso, Indiana
235
mi
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Valparaiso, IN
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1236.1.561 Clinical Research Center of Cape Cod
131 Attucks Lane
West Yarmouth, Massachusetts 02601
674
mi
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West Yarmouth, MA
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1218.74.01069 Boehringer Ingelheim Investigational Site
Westlake Village, California
2000
mi
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Westlake Village, CA
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1199.14.1097 Boehringer Ingelheim Investigational Site
Wichita, Kansas
785
mi
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Wichita, KS
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