Prospective Investigation of Multiple Sclerosis in the Three Rivers Region



Status:Recruiting
Conditions:Neurology, Neurology, Multiple Sclerosis
Therapuetic Areas:Neurology, Other
Healthy:No
Age Range:7 - Any
Updated:12/23/2018
Start Date:December 2016
End Date:January 2047
Contact:Zongqi Xia, MD, PhD
Email:msstudy2@pitt.edu
Phone:412-383-5377

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Trial Summary
Trial Overview
Inclusion Criteria
In this longitudinal prospective natural history study of multiple sclerosis (MS), the
overarching goal is to understand the factors that influence individual variation in disease
trajectory and treatment response and pave the way for realizing precision medicine in MS.
Because MS is a chronic neurological disorder, this observational cohort study will span a
30-year time frame.

Research Activities: Initial Questionnaire, Questionnaire for Self-Reported Outcomes,
Biological Sample Collection (Blood, Stool, Urine, Cerebrospinal fluid), Genetic Analysis,
Standard Quantitative Assessment of Function, Cognitive Assessment, Neuroimaging, Biometric
Sensors, and Social Network Questionnaire.

Inclusion Criteria:

- Inclusion criteria for MS patients include:

1. willing and able to give consent

2. age 7 years or older

3. diagnosis of multiple sclerosis or related disorders, including a first central
nervous system demyelinating episode with a positive MRI scan or abnormal MRI
scans characteristic of MS but no clinical symptoms of the disease

- For healthy controls:

1. Age 7 years or older

2. Willing and able to provide consent (for >=18 years) or assent with permission
from at least one of the child's parents (for <18 years)

3. No known personal history of multiple sclerosis or related disorders

4. No other chronic diseases

5. Family members, unrelated household controls, or controls from the general
population could be eligible

There is no exclusion criteria.
We found this trial at
1
site
University of Pittsburgh
4200 Fifth Ave
Pittsburgh, Pennsylvania 15260
(412) 624-4141
Phone: 412-383-5377
University of Pittsburgh The University of Pittsburgh is a state-related research university, founded as the...
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