Study of MK-7162 in Combination With Pembrolizumab (MK-3475) in Adult Participants With Advanced Solid Tumors (MK-7162-002)

Age Range:18 - Any
Start Date:December 6, 2017
End Date:January 13, 2021
Contact:Toll Free Number

Use our guide to learn which trials are right for you!

Phase 1b Open-label Study of MK-7162 in Combination With Pembrolizumab (MK-3475) +/- Other Therapies in Participants With Advanced Solid Tumors

The purposes of this study are to: 1) determine the safety and tolerability of MK-7162 when
administered in combination with pembrolizumab (MK-3475), 2) establish a preliminary
recommended Phase 2 dose (RP2D) of MK-7162 when administered in combination with
pembrolizumab, and 3) assess the pharmacokinetics and pharmacodynamics of MK-7162 when
administered in combination with pembrolizumab and other therapies to adult participants with
advanced solid tumors.

Inclusion Criteria:

- Has a histologically- or cytologically-confirmed advanced/metastatic solid tumor by
pathology report and have received, or been intolerant to, or been ineligible for all
treatment known to confer clinical benefit. Participants with solid tumors of any type
are eligible for enrollment.

- Has stage III or stage IV disease that is not surgically resectable.

- Has measureable disease by RECIST 1.1 criteria as assessed by the local site

- Has 1 or more discrete malignant lesions that are amenable to ≥2 separate biopsies
guided by one of the following modalities: visual inspection, ultrasound guidance, or
cross sectional image guidance (computed tomography/magnetic resonance imaging

- Has an evaluable baseline tumor sample to submit for analysis.

- Has a performance status of 0 or 1 on the Eastern Cooperative Oncology Group (ECOG)
Performance Scale.

- Demonstrates adequate organ function.

- If male, must agree to use contraception and refrain from donating sperm during the
treatment period and for ≥120 days after last dose of study treatment.

- If female, is not pregnant or breastfeeding, and agrees to use contraception during
the treatment period and for ≥120 days after last dose of study treatment.

Exclusion Criteria:

- Has a history of a second malignancy, unless potentially curative treatment has been
completed with no evidence of malignancy for 2 years. (Note: The time requirement does
not apply to participants who underwent successful definitive resection of basal cell
carcinoma of the skin, superficial bladder cancer, in situ cervical cancer, or other
in-situ cancers.)

- Has a known active central nervous system metastasis and/or carcinomatous meningitis.

- Has had a severe hypersensitivity reaction to treatment with a monoclonal
antibody/components of the study treatment(s).

- Has an active autoimmune disease that has required systemic treatment in the past 2
years except vitiligo or resolved childhood asthma/atopy.

- Has a history of vasculitis.

- Has an active infection requiring systemic therapy.

- Has symptomatic ascites or pleural effusion.

- Has interstitial lung disease that has required oral or intravenous glucocorticoids to
assist with management.

- Has a history of (non-infectious) pneumonitis that required steroids or has current

- Has undergone prior allogeneic hematopoietic stem cell transplantation within the last
5 years. (Note: Participants who have had a stem cell transplant >5 years ago are
eligible as long as there are no symptoms of graft-versus-host disease [GVHD].)

- Has a known history of human immunodeficiency virus (HIV) infection.

- Has known active Hepatitis B or known active Hepatitis C virus infection.

- Is pregnant or breastfeeding, or expecting to conceive or father children within the
projected duration of the study.

- Has not fully recovered from any effects of major surgery without significant
detectable infection.

- Has received prior systemic anti-cancer therapy including investigational agents or
has used an investigational device within 28 days prior to the first dose of study
treatment. (Notes: Participants must have recovered from all AEs due to previous
therapies to ≤Grade 1 or baseline. Prior exposure to immunotherapeutics is allowed,
including programmed cell death-1 (PD-1) and programmed cell death-ligand 1 (PD-L1)
inhibitors, provided the participant did not experience ≥Grade 3 drug-related toxicity
on monotherapy with a PD-1 or PD-L1 inhibitor.

- Has been previously treated with an Indoleamine-2,3-dioxygenase-1 (IDO1) inhibitor
(e.g., epacadostat, BMS-986205)

- Has received prior radiotherapy within 2 weeks of start of study treatment.

- Is receiving an monoamine oxidase-inhibitors (MAOI) or any drug which has significant
MAOI activity (e.g., meperidine, linezolid, methylene blue) within the 21 days before
screening, or has a history of Serotonin Syndrome after receiving serotonergic drugs.

- Is expected to require any non-protocol antineoplastic therapy while on study.

- Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy
in excess of replacement doses (the equivalent of prednisone ≤10 mg/day is
acceptable), or on any other form of immunosuppressive medication.

- Has received a live-virus vaccine within 30 days prior to first dose of study
We found this trial at
Grand Rapids, Michigan 49503
Phone: 616-954-5551
Grand Rapids, MI
Click here to add this to my saved trials
New York, New York 10016
Phone: 212-731-5445
New York, NY
Click here to add this to my saved trials
Santa Monica, California 90404
Phone: 310-829-5471
Santa Monica, CA
Click here to add this to my saved trials
Toronto, Ontario
Phone: 4169462911
Click here to add this to my saved trials