An Investigational Immunotherapy Study of BMS-986249 Alone and in Combination With Nivolumab in Solid Cancers That Are Advanced or Have Spread



Status:Recruiting
Conditions:Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:2/2/2019
Start Date:December 5, 2017
End Date:July 30, 2020
Contact:Recruiting sites have contact information. Please contact the sites directly. If there is no contact information
Email:Clinical.Trials@bms.com
Phone:please email:

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A Phase 1/2 First-in-Human Study of BMS-986249 Alone and in Combination With Nivolumab in Advanced Solid Tumors

The purpose of this study is to determine whether BMS-986249 both by itself and in
combination with Nivolumab is safe and tolerable in the treatment of advanced solid tumors


For more information regarding Bristol-Myers Squibb Clinical Trial participation, please
visit www.BMSStudyConnect.com

Inclusion Criteria:

- Histologic or cytologic confirmation of a solid tumor that is advanced (metastatic,
recurrent, and/or unresectable) with measurable disease and have at least 1 lesion
accessible for biopsy

- Eastern Cooperative Oncology Group Performance Status of 0 or 1

- Participants must have received, and then progressed, relapsed, or been intolerant to,
at least 1 standard treatment regimen in the advanced or metastatic setting according
to solid tumor histologies

Exclusion Criteria:

- Participants with primary CNS malignancies or tumors with CNS metastases as the only
site of disease, will be excluded

- Prior anti-cancer treatments such as chemotherapy, radiotherapy, or hormonal are
permitted

- Participants with other active malignancy requiring concurrent intervention

Other protocol defined inclusion/exclusion criteria could apply
We found this trial at
19
sites
Greenville, South Carolina 29615
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Greenville, SC
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3400 N Charles St
Baltimore, Maryland 21205
410-516-8000
Johns Hopkins University The Johns Hopkins University opened in 1876, with the inauguration of its...
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Baltimore, MD
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Aurora, Colorado 80045
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Aurora, CO
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Austin, Texas 78705
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Austin, TX
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Dallas, TX
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Denver, Colorado 80218
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Denver, CO
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Eugene, OR
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92 2nd St
Hackensack, New Jersey 07601
(201) 996-5900
Phone: 551-996-5499
John Theurer Cancer Center at the Hackensack University Medical Center The mission of the John...
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Hackensack, NJ
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Houston, Texas 77030
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Houston, TX
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Leesburg, VA
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Miami, FL
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New York, NY
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1275 York Ave
New York, New York 10021
(212) 639-2000
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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New York, NY
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5900 Lake Wright Dr
Norfolk, Virginia 23502
(757) 466-8683
Virginia Oncology Associates Virginia Oncology Associates is an oncology and hematology practice of physicians, specializing...
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Norfolk, VA
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116 Pacific Highway
North Sydney, New South Wales 2060
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North Sydney,
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Philadelphia, Pennsylvania 19102
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Philadelphia, PA
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Portland, Oregon 97213
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Portland, OR
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San Antonio, TX
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Tyler, Texas 75702
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from
Tyler, TX
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