Effect of D-amphetamine on Reward Functioning

Inclusion Criteria:

- Healthy individuals

Exclusion Criteria:

- Individuals with a body mass index (BMI) <19 or >26, as this alters dosing
requirements

- Individuals with high blood pressure, abnormal Electrocardiography (EKG), any medical
condition requiring regular medication (except birth control), any other regular use
of a drug or supplement with potentially hazardous interactions with d-amphetamine
(e.g. St. John's wort), or any other medical contraindication to amphetamine
administration as determined by our study physician

- Individuals who report no prior experience with recreational drugs of any kind
(including alcohol), or who report a previous adverse reaction to amphetamine

- Individuals with a current Diagnostic and Statistical Manual of Mental Disorders-V
(DSM-V) Axis I diagnosis, excluding mild Substance Use Disorders (≤ 3 symptoms)

- Individuals with a lifetime history of moderate to severe Substance Use Disorder (≥ 4
symptoms), mania or psychosis.

- Women who are pregnant.

- individuals smoking more than 10 cigarettes per week will also be excluded, to avoid
confounding the effects of nicotine withdrawal with the effects of the study
drugs/procedures, as participants will not be allowed to smoke during the sessions.

- individuals with less than a high-school level of education or fluency in English will
be excluded as our questionnaires require high-school level fluency in English, and
have not been translated and validated in other languages.