A Study of Memory, Thinking, and Brain Imaging in Adults With Histiocytosis



Status:Recruiting
Conditions:Infectious Disease
Therapuetic Areas:Immunology / Infectious Diseases
Healthy:No
Age Range:18 - Any
Updated:12/6/2018
Start Date:April 7, 2017
End Date:April 2020
Contact:Eli Diamond, MD
Email:diamone1@mskcc.org
Phone:212-610-0243

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A Clinical, Structural, and Functional Neuroimaging Study of Cognition in Adults With Erdheim-Chester Disease, Langerhans Cell Histiocytosis, Rosai-Dorfman Disease, and Other Histiocytoses

The purpose of this study is to try to understand how histopcytosis can cause symptoms or
problems in the brain. The tests being done in the study will look at memory and thinking as
well as brain function via MRI scan.


Inclusion Criteria:

- Age greater than or equal to 18 years.

- Fluency in English

- Diagnosis of a histiocytic disorder as determined, in the opinion of the study PI, by
a corroborating constellation of histopathology, clinical, and/or radiologic findings.

- Will undergo Standard of Care MRI.

Exclusion Criteria:

- Known intracranial involvement of histiocytosis (including dura, leptomeninges and
brain parenchyma)

- Prior stroke or intracranial hemorrhage

- Other (non-histiocytic) intracranial neoplasm or neurological disorder deemed by the
PI or Co-PI to confound neuroimaging studies (e.g., demyelinating disease)

- Existing diagnosis of a psychiatric disorder or untreated mood disturbance

- Existing diagnosis of a neurodegenerative disease, such as Alzheimer's disease

- Chronic or daily excessive alcohol consumption as determined by the PI.

- History of chronic use of corticosteroids, defined as continuous treatment for six
months or longer at any time in the past

- History of severe claustrophobia or other contraindications to patient SOC brain MRI

- Prior intravenous cytarabine or cladribine

- Other current or prior treatments (e.g., high-dose chemotherapy for a different
cancer) deemed by the PI or Co-PI to confound imaging studies or cognitive performance
We found this trial at
4
sites
136 Mountainview Boulevard
Basking Ridge, New Jersey 07920
Phone: 212-610-0243
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Commack, New York 11725
Phone: 212-610-0243
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Harrison, New York
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Middletown, New Jersey 07748
Phone: 212-610-0243
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