Resuscitation With Plasma in Surgical and Trauma Patients With Septic Shock

Inclusion Criteria:

- Patients meeting the following criteria will be enrolled: Have a Sepsis Screening
Score (SSS) ≥ 4 with a suspected source of infection (Table 1); and Written informed
consent obtained

- Patients meeting any of the following criteria will be randomized: Hypotension with
MAP < 65 mmHg; Lactic acid > 4 mmol/L; Altered mental status; and Decreased urine
output of < 0.5 mL/kg in the past hour.

Exclusion Criteria:

- Pregnancy

- Prisoners

- Traumatic brain injury

- Evidence of ongoing hemorrhage, history of congenital bleeding disorders, therapeutic
anticoagulation

- History of myocardial infarction or congestive heart failure

- History of acute cerebral vascular event

- Major burns (>20% total body surface area)

- History of adverse reactions to blood product transfusion

- Contraindications to blood transfusions (eg. Jehovah's Witness)

- Contraindications to central venous line and arterial line placement

- On renal replacement therapy or hemodialysis

- Do-Not-Resuscitate or Comfort Care status

- Participation in another interventional study

- Pending transfer to another unit within the hospital that is not STICU or SIMU