ZIMURA in Combination With LUCENTIS in Patients With Neovascular Age Related Macular Degeneration (NVAMD)



Status:Completed
Conditions:Ocular
Therapuetic Areas:Ophthalmology
Healthy:No
Age Range:50 - Any
Updated:11/17/2018
Start Date:October 11, 2017
End Date:October 18, 2018

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A Phase 2A Open-label Trial to Assess the Safety of ZIMURA™ (Anti-C5) Administered in Combination With LUCENTIS® 0.5 mg in Treatment Naive Subjects With Neovascular Age Related Macular Degeneration

To assess the safety of intravitreal Zimura™ (complement factor C5 inhibitor) administered in
combination with Lucentis® 0.5 mg in treatment naïve subjects with neovascular age related
macular degeneration (NVAMD)


Inclusion Criteria:

- Active subfoveal NVAMD

Exclusion Criteria:

- History or evidence of severe cardiac disease

- Any major surgical procedure within one month of trial entry

- Subjects with a clinically significant laboratory value

- Any treatment with an investigational agent in the past 60 days for any condition

- Women who are pregnant or nursing

- Known serious allergies to the fluorescein dye used in angiography, povidone iodine,
to the components of the ranibizumab formulation, or to the components of the Zimura
formulation

- Any prior treatment for AMD other than oral supplements of vitamins and minerals
We found this trial at
24
sites
Altamonte Springs, Florida 32701
2541
mi
from 98109
Altamonte Springs, FL
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1582
mi
from 98109
Abilene, TX
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Beverly Hills, California 90211
959
mi
from 98109
Beverly Hills, CA
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Boston, Massachusetts 02114
2485
mi
from 98109
Boston, MA
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?
mi
from 98109
Budapest,
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Fullerton, California 92835
975
mi
from 98109
Fullerton, CA
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Golden, Colorado 80401
1010
mi
from 98109
Golden, CO
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710 Coronado Center Drive
Henderson, Nevada 89052
884
mi
from 98109
Henderson, NV
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Ladson, South Carolina 29456
2406
mi
from 98109
Ladson, SC
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502 East New Haven Avenue
Melbourne, Florida 32901
2603
mi
from 98109
Melbourne, FL
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Minneapolis, Minnesota 55435
1390
mi
from 98109
Minneapolis, MN
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Peoria, Illinois 61615
1678
mi
from 98109
Peoria, IL
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Philadelphia, Pennsylvania 19107
2373
mi
from 98109
Philadelphia, PA
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Phoenix, Arizona 85014
1113
mi
from 98109
Phoenix, AZ
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Portland, Oregon 97210
147
mi
from 98109
Portland, OR
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Redlands, California 92374
974
mi
from 98109
Redlands, CA
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Reno, Nevada 89502
578
mi
from 98109
Reno, NV
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Sacramento, California 95819
627
mi
from 98109
Sacramento, CA
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Santa Ana, California 92705
987
mi
from 98109
Santa Ana, CA
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3107 East Genesee Street
Syracuse, New York 13224
2234
mi
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Syracuse, NY
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Tucson, Arizona 85704
1220
mi
from 98109
Tucson, AZ
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Tucson, Arizona 85710
1220
mi
from 98109
Tucson, AZ
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1435
mi
from 98109
Wichita, KS
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Willow Park, Texas 76087
1892
mi
from 98109
Willow Park, TX
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