S-Equol in Alzheimer's Disease 2 Trial



Status:Recruiting
Conditions:Alzheimer Disease
Therapuetic Areas:Neurology
Healthy:No
Age Range:50 - 90
Updated:3/15/2019
Start Date:May 5, 2017
End Date:October 30, 2019
Contact:Annette Becker
Email:abecker@kumc.edu
Phone:(913) 945-7674

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S-Equol in Alzheimer's Disease 2 (SEAD2) Trial

By doing this study researchers hope to learn if S-equol, a compound that acts like estrogen
in the body, causes an increase in mitochondrial activity. Researchers also hope to determine
the safety and tolerability of a therapeutic dose of S-equol and whether or not it influences
cognition.


Inclusion Criteria:

- Have a diagnosis of Alzheimer's Disease (AD)

- Have a study partner who has a close relationship with the participant and will attend
study visits with the participant

- Do not possess an Alkylphenol ethoxylates 4 (APOE4) variant of the APOE gene

- Speak English as their primary language

- Have not had any medication changes within the past 30 days

Exclusion Criteria:

- Reside in a nursing home or dementia special care unit

- Have a potentially confounding, serious medical risk such as insulin-requiring
diabetes, any history of cancer that required a chemotherapy or radiation therapy
intervention within the past 5 years, or a recent cardiac event

- Have any clinically significant abnormal safety laboratory values at the SEAD2
screening visit

- Have any clinically significant abnormal findings on vital signs measurements, or on
physical or neurological examination at the SEAD2 screening visit

- Use any type of systemic estrogen or testosterone replacement therapy

- Has participated in another clinical trial or received any investigational drug or
investigational therapy within 30 days before the screening visit
We found this trial at
2
sites
3901 Rainbow Blvd
Kansas City, Kansas 66160
(913) 588-5000
University of Kansas Medical Center The University of Kansas Medical Center serves Kansas through excellence...
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