Safety, PK, and PD Study of IVRs Releasing TFV and LNG

Age Range:18 - 50
Start Date:September 28, 2017
End Date:December 31, 2018
Contact:Medical Director

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Phase I, 90-Day Safety, Pharmacokinetic, And Pharmacodynamic Study Of Intravaginal Rings Releasing Tenofovir And Levonorgestrel

This multi-center Phase I study is designed to characterize the safety, PK, and PD of TFV/LNG
IVR to assess systemic and genital tract bioavailability in healthy women. The IVRs to be
used in the study are TFV/LNG IVR (8-10mg per day/20μg per day) or placebo IVR. Samples will
be obtained before, during and after 90 days of continuous or interrupted IVR use.

The purpose of this multi-center Phase I protocol, titled Phase I, 90-Day Safety,
Pharmacokinetic, and Pharmacodynamic Study of Intravaginal Rings Releasing Tenofovir and
Levonorgestrel is to assess the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of
the Tenofovir/Levonorgestrel Intravaginal Ring (TFV/LNG IVR).

The study will enroll healthy, non-pregnant, ovulatory, HIV-uninfected women aged 18 to 50
with a body mass index (BMI) less than 30 kg/m2, regular menstrual cycles (approximately
26-35 days) by participant report, and willing to use non-spermicidal condoms for sex and
follow other study restrictions. Women will be protected from pregnancy by abstinence from
vaginal intercourse or agreeing to consistently use condoms.

The enrollment goal is for approximately 60 participants to complete the study. A subset of
approximately 20 women will be selected for an in-depth interview to take place during the
first month of IVR use and again after 90 days of use.

Women will be randomized to one of four arms: TFV/LNG IVR (8-10mg per day/20μg per day) for
90 days (Continuous), TFV/LNG IVR (8-10mg per day/20μg per day) for 3x28 days (Interrupted),
placebo IVR for 90 days (Continuous), or placebo IVR for 3x28 days (Interrupted) and will
undergo blood, cervicovaginal and rectal fluid sample collections, and cervicovaginal tissue
collections for PK and PD assessments before, during and after 90 days of continuous or
interrupted IVR use.

Inclusion Criteria:

- Female, age 18-50 years, inclusive

- General good health (by volunteer history and per investigator discretion) without any
clinically significant systemic disease (including, but not limited to significant
liver disease/hepatitis, gastrointestinal disease, kidney disease, thyroid disease,
osteoporosis or bone disease, and diabetes) and with an intact gastrointestinal tract,
uterus, and cervix.

- Currently having regular menstrual cycles (approximately 26-35 days) by participant

- History of Pap smears and follow-up consistent with standard clinical practice as
outlined in the Study Manual or willing to undergo a Pap smear at Visit 1

- Protected from pregnancy by one of the following:

- Sterilization of either partner

- Abstinence from vaginal intercourse

- Consistent use of non-spermicidal condoms

- Willing to abstain from use of vaginal products (other than the study product and
condoms) including tampons (except for menses), spermicides, lubricants, and douches
for the whole study

- Willing to abstain from any vaginal and anal intercourse/activity starting 48 hours
before cervical mucus collection, as possible, and 48 hours before Visits 4 and 29,
and for 5 days after tissue collection

- Vaginal and cervical anatomy that, in the opinion of the investigator, lends itself to
easy genital tract sample collection

- Negative urine pregnancy test

- P4 ≥3 ng/ml

- Willing to give voluntary consent and sign an informed consent form

- Willing and able to comply with protocol requirements

Exclusion Criteria:

- BMI ≥ 30 kg/m2

- History of hysterectomy

- Currently pregnant or within two calendar months from the last pregnancy outcome.

Note: If recently pregnant, must have had at least two spontaneous menses since pregnancy

- Use of any hormonal contraceptive method in the last 3 months (oral, transdermal,
transvaginal, implant, or hormonal intrauterine contraceptive device)

- Injection of Depo-Provera in the last 10 months

- Use of copper IUD

- Currently breastfeeding or having breastfed an infant in the last two months, or
planning to breastfeed during the course of the study

- History of sensitivity/allergy to any component of the study products, topical
anesthetic, or to both silver nitrate and Monsel's solution

- Contraindication to LNG

- In the last three months, diagnosed with or treated for any STI or pelvic inflammatory
disease. Note: Women with a history of genital herpes or condylomata who have been
asymptomatic for at least six months may be considered for eligibility.

- Nugent score greater than or equal to 7 or symptomatic bacterial vaginosis (BV) as
defined by Amsel's criteria

- Positive test for Trichomonas vaginalis (TV), Neisseria gonorrhea (GC), Chlamydia
trachomatis (CT), HIV-1, or Hepatitis B surface antigen (HBsAg)

- Known bleeding disorder, including deep vein thrombosis (DVT) and pulmonary embolism
(PE), or those that could lead to prolonged or continuous bleeding with biopsy

- Chronic or acute vulvar or vaginal symptoms (pain, irritation, spotting/bleeding,
discharge, etc.)

- Known current drug or alcohol abuse which could impact study compliance

- Grade 2 or higher laboratory abnormality, per the 2014 update of the Division of AIDS,
National Institute of Allergy and Infectious Disease (DAIDS) Table for Grading the
Severity of Adverse Events, or clinically significant laboratory abnormality as
determined by the clinician

- Systemic use in the last two weeks or anticipated use during the study of any of the
following: corticosteroids, antibiotics, anticoagulants or other drugs known to
prolong bleeding and/or clotting, antifungals, or antivirals or antiretrovirals (e.g.
acyclovir, valacyclovir, Viread®, Atripla®, Emtriva®, or Complera®), or CYP3A4
inducers or inhibitors as detailed in the Study Manual (e.g., St. John's Wort or

Note: Participants should avoid non-steroidal anti-inflammatory drugs (NSAIDs) except for
treatment of dysmenorrhea during menses. Participants may use acetaminophen on an as-needed
but not daily basis during the study.

- Participation in any other investigational trial with use of a drug/device within the
last 30 days or planned participation in any other investigational trial with use of a
drug/device during the study

- History of gynecological procedures (including genital piercing) on the external
genitalia, vagina, or cervix within the last 14 days

- Abnormal finding on laboratory or physical examination or a social or medical
condition in the volunteer which, in the opinion of the investigator, would make
participation in the study unsafe or would complicate interpretation of data
We found this trial at
Norfolk, Virginia 23507
Phone: 703-446-5600
Norfolk, VA
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Santo Domingo,
Santo Domingo,
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