A Study of Rapastinel for Rapid Treatment of Depression and Suicidality in Major Depressive Disorder



Status:Recruiting
Conditions:Depression, Depression, Major Depression Disorder (MDD)
Therapuetic Areas:Psychiatry / Psychology, Pulmonary / Respiratory Diseases
Healthy:No
Age Range:18 - 65
Updated:12/9/2018
Start Date:December 5, 2017
End Date:January 1, 2020
Contact:Clinical Trials Registry Team
Email:IR-CTRegistration@Allergan.com
Phone:1-877-277-8566

Use our guide to learn which trials are right for you!

A Randomized, Double-blind, Placebo-controlled, Multicenter, Efficacy and Safety Study of Rapastinel for Rapid Treatment of Symptoms of Depression and Suicidality in Adult Patients With Major Depressive Disorder

The study will evaluate the efficacy, safety, and tolerability of 450 milligrams (mg) of
Rapastinel, compared to placebo in adult patients with major depressive disorder (MDD) who
are at imminent risk of suicide.


Inclusion Criteria:

- Meet Diagnostic and Statistical Manual of Mental Disorders - Fifth Edition (DSM-5)
criteria for MDD

- Current major Depressive episode of at least 4 weeks and not exceeding 24 months in
duration at visit 1

- Have current, ongoing suicidality (ideation or behavior) of sufficient severity to
warrant hospitalization based on the judgment of the investigator

- If female of childbearing potential, have a negative serum β-human chorionic
gonadotropin (β-hCG) pregnancy test.

Exclusion Criteria:

- DSM-5-based diagnosis of any disorder other than MDD that was the primary focus of
treatment within 1 month before Visit 1.

- Lifetime history or currently meet DSM-5 criteria for:

1. Schizophrenia spectrum or other psychotic disorder

2. Bipolar or related disorder

3. Major neurocognitive disorder

4. Neurodevelopmental disorder of greater than mild severity or of a severity that
impacts the participant's ability to consent, follow study directions, or
otherwise safely participate in the study.

5. Dissociative disorder

6. Posttraumatic stress disorder

7. MDD with psychotic features

- Significant homicidal ideation or at imminent risk of injuring others or causing
significant damage to property, as judged by the investigator.

- Prior participation in any investigational study of rapastinel/GLYX-13
We found this trial at
28
sites
Hines, Illinois 60141
?
mi
from
Hines, IL
Click here to add this to my saved trials
1200 Moursund Street
Houston, Texas 77030
(713) 798-4951
Baylor College of Medicine Baylor College of Medicine in Houston, the only private medical school...
?
mi
from
Houston, TX
Click here to add this to my saved trials
101 Jessup Hall
Iowa City, Iowa 52242
(319) 335-3500
University of Iowa With just over 30,000 students, the University of Iowa is one of...
?
mi
from
Iowa City, IA
Click here to add this to my saved trials
Atlanta, Georgia 30331
Phone: 404-881-5800
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
?
mi
from
Birmingham, AL
Click here to add this to my saved trials
Chapel Hill, North Carolina 27599
(919) 962-2211
Phone: 203-414-0007
Univ of North Carolina Carolina’s vibrant people and programs attest to the University’s long-standing place...
?
mi
from
Chapel Hill, NC
Click here to add this to my saved trials
Cincinnati, Ohio 45220
Phone: 513-226-3571
?
mi
from
Cincinnati, OH
Click here to add this to my saved trials
6150 Diamond Centre Court
Fort Myers, Florida 33912
?
mi
from
Fort Myers, FL
Click here to add this to my saved trials
Gaithersburg, Maryland 20877
Phone: 301-251-4702
?
mi
from
Gaithersburg, MD
Click here to add this to my saved trials
Garden Grove, California 92845
Phone: 844-562-1212
?
mi
from
Garden Grove, CA
Click here to add this to my saved trials
Glendale, California 91204
Phone: 888-255-5798
?
mi
from
Glendale, CA
Click here to add this to my saved trials
Hartford, Connecticut 06106
Phone: 860-919-1574
?
mi
from
Hartford, CT
Click here to add this to my saved trials
Hialeah, Florida 33012
Phone: 800-730-7692
?
mi
from
Hialeah, FL
Click here to add this to my saved trials
Hinsdale, Illinois 60521
?
mi
from
Hinsdale, IL
Click here to add this to my saved trials
Hoffman Estates, Illinois 60169
Phone: 847-882-1600
?
mi
from
Hoffman Estates, IL
Click here to add this to my saved trials
Lake Charles, Louisiana 70601
Phone: 337-515-5212
?
mi
from
Lake Charles, LA
Click here to add this to my saved trials
Las Vegas, Nevada 89102
Phone: 877-261-5701
?
mi
from
Las Vegas, NV
Click here to add this to my saved trials
?
mi
from
Long Beach, CA
Click here to add this to my saved trials
1428 Madison Ave
New York, New York 10029
(212) 241-6500
Phone: 212-241-6500
Icahn School of Medicine at Mount Sinai Icahn School of Medicine at Mount Sinai is...
?
mi
from
New York, NY
Click here to add this to my saved trials
Oakland Park, Florida 33334
Phone: 954-900-7649
?
mi
from
Oakland Park, FL
Click here to add this to my saved trials
14860 Roscoe Boulevard
Panorama City, California 91402
Phone: 844-283-3649
?
mi
from
Panorama City, CA
Click here to add this to my saved trials
?
mi
from
Philadelphia, PA
Click here to add this to my saved trials
Philadelphia, Pennsylvania 19104
?
mi
from
Philadelphia, PA
Click here to add this to my saved trials
Richardson, Texas 75080
Phone: 214-396-4844
?
mi
from
Richardson, TX
Click here to add this to my saved trials
1906 Belleview Avenue Southeast
Roanoke, Virginia 24014
Phone: 540-981-8582
?
mi
from
Roanoke, VA
Click here to add this to my saved trials
Salem, Virginia 24153
Phone: 540-982-2463
?
mi
from
Salem, VA
Click here to add this to my saved trials
Salisbury, North Carolina 28144
?
mi
from
Salisbury, NC
Click here to add this to my saved trials
950 Campbell Ave
West Haven, Connecticut 06516
(203) 932-5711
Phone: 203-932-5711
VA Connecticut Healthcare System VA Connecticut encompasses an inpatient facility and Ambulatory Care Center in...
?
mi
from
West Haven, CT
Click here to add this to my saved trials