Evaluation of Fluciclovine Uptake in Patients With Cervical, Ovarian Epithelial or Endometrial Cancers.

Conditions:Ovarian Cancer, Cervical Cancer, Cervical Cancer, Cervical Cancer, Cancer, Cancer, Women's Studies, Endometrial Cancer
Therapuetic Areas:Oncology, Reproductive
Age Range:18 - Any
Start Date:November 14, 2018
End Date:December 2019
Contact:Rachel Ochoa, BA

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Evaluation of Fluciclovine Uptake in Patients With Cervical, Ovarian Epithelial or Endometrial Cancers. Pilot Study.

An important part of staging and deciding the method of treatment is knowing areas of how
cancer is involved. Diagnostic imaging is often used to determine the location of the cancer
using techniques like nuclear medicine, MRI (magnetic resonance imaging), CT (computerized
tomography), and ultrasound. Each technique looks for cancer in different ways and are often
used together to make a better determination of the extent of disease.

One of the techniques used in cancer imaging is PET/CT. This technique combines a nuclear
medicine study (PET or positron emission tomography) with CT performing both scans at the
same time. PET/CT most commonly uses a radioactive sugar (FDG or fluorodeoxyglucose) to
detect the cancer. The problem with FDG is that it is excreted by the kidneys and collected
in the bladder. Even though the bladder is emptied prior to the scan, the FDG activity
present there may interfere with the detection of small areas of cancer involvement in lymph
nodes or adjacent areas. It is because of this that PET/CT using FDG is infrequently used in
gynecological cancers.

This purpose of this study is to evaluate if 18F-fluciclovine can be used to help determine
the extent of gynecological cancers. 18F-fluciclovine (also known as AXUMIN) is a radioactive
tracer which has been approved by the FDAFood and Drug Administration (FDA) for use in
patients with prostate cancer. 18F-fluciclovine has much less excretion through the kidneys
which improves the PET/CT imaging of the pelvis.

Inclusion Criteria:

- GYN cancer (ovarian, endometrial, or cervical) was biopsy-proven and/or schedule for
subsequent surgery based on clinical presentation (imaging, markers)

- Age ≥ 18 years.

- Can tolerate 18F-fluciclovine PET/CT exam (can lie on her back for the duration of the

- Ability to understand and the willingness to sign a written informed consent.

Exclusion Criteria:

- Ongoing systemic therapy for cancer

- Systemic therapy for cancer in the past 3 months

- Inability to tolerate 18F-fluciclovine PET/CT exam

- Pregnant or lactating women
We found this trial at
2160 South 1st Avenue
Maywood, Illinois 60153
(888) 584-7888
Principal Investigator: Bital Savir-Baruch, M.D.
Phone: 708-216-2508
Loyola University Medical Center Loyola University Health System is committed to excellence in patient care...
Maywood, IL
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