Brain Function in Adolescent Eating Disorders and Healthy Peers



Status:Recruiting
Conditions:Psychiatric, Eating Disorder
Therapuetic Areas:Psychiatry / Psychology
Healthy:No
Age Range:14 - 17
Updated:11/23/2017
Start Date:July 21, 2017
End Date:June 2022
Contact:Taylor Perry, BS
Email:trperry@ucsd.edu
Phone:858-246-2660

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Neurocircuitry of Temperament and Motivated Behavior in Adolescent Eating Disorders

This study of adolescent eating disorders (ED) will examine the association of
temperament-based classifications, brain activation during incentive processing, and ED
symptoms at time of scan and 1 year later to better understand the neurobiology and symptoms
of ED. We will recruit 150 females currently ill with an ED and 50 controls ages 14-17 to
investigate how temperaments reflecting greater inhibition, impulsivity, or effortful control
correspond to 1) clinical symptoms and 2) the brain's response to anticipation and outcome of
salient stimuli, and 3) by collecting follow-up clinical data one year later, identify how
temperament-based subtypes predict ED symptom change (e.g., clinical prediction). Data
collection will rely on a technology called functional magnetic resonance imaging (fMRI).


Inclusion Criteria:

- Female

- Meet DSM-V criteria for an Eating Disorder or Never met criteria for an Eating
disorder

- Medically stable

- Post-Pubertal (must have started menses, but subsequent loss of menses secondary to ED
is fine).

Exclusion Criteria:

- Psychotic illness/other mental illness requiring hospitalization

- Current dependence on drugs or alcohol

- Physical conditions known to influence eating or weight (e.g, diabetes mellitus,
pregnancy).

- On psychoactive medication

- Organic brain syndromes, delirium, psychotic disorders, or intellectual disability

- Neurological or medical disorders such as seizure disorder

- Any contraindication to undergoing an MRI

- Major depressive disorder

- Left handed
We found this trial at
1
site
San Diego, California 92093
Principal Investigator: Christina Wierenga, PhD
Phone: 858-246-2660
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San Diego, CA
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