PF-06804103 Dose Escalation in HER2 Positive Solid Tumors



Status:Recruiting
Conditions:Breast Cancer, Lung Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:2/7/2019
Start Date:November 1, 2017
End Date:June 22, 2021
Contact:Pfizer CT.gov Call Center
Email:ClinicalTrials.gov_Inquiries@pfizer.com
Phone:1-800-718-1021

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A PHASE 1 DOSE ESCALATION STUDY EVALUATING THE SAFETY AND TOLERABILITY OF PF-06804103 IN PATIENTS WITH HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2 (HER2) POSITIVE SOLID TUMORS

The study will evaluate the safety, pharmacokinetics and pharmacodynamics of increasing doses
of PF-06804103 in patients with HER2 positive solid tumors. The study will expand to look at
the selected dose in patients with breast cancer, gastric cancer and non-small cell lung
cancer


Inclusion Criteria:

- HER2 positive breast cancer or gastric cancer that is resistant to standard therapy or
for which no standard therapy is available

- Performance status of 0 or 1

- Adequate bone marrow, kidney and liver function

Exclusion Criteria:

- Known CNS disease including, but not limited to, metastases

- History of exposure to certain cumulative doses of anthracyclines

- Grade 3 or higher hypersensitivity reaction to prior receipt of any antibody therapy

- Active and clinically significant bacterial, fungal, or viral infection

- Abnormal cardiac function defined by a LVEF <50% by ECHO or MUGA

- Patients with previous history or active interstitial lung disease or pulmonary
fibrosis, or a history of other clinically significant lung diseases
We found this trial at
14
sites
8700 Beverly Blvd # 8211
Los Angeles, California 90048
(1-800-233-2771)
Cedars Sinai Med Ctr Cedars-Sinai is known for providing the highest quality patient care. Our...
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1515 Holcombe Blvd
Houston, Texas 77030
 713-792-2121
University of Texas M.D. Anderson Cancer Center The mission of The University of Texas MD...
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Los Angeles, California 90095
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Milano,
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Santa Monica, CA
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2020 Santa Monica Boulevard
Santa Monica, California 90404
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Santa Monica, California 90404
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Tucson, AZ
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