Vitamin D and Immune Mechanisms of Hypertension in Type 2 Diabetics



Status:Recruiting
Conditions:High Blood Pressure (Hypertension), Other Indications, Gastrointestinal, Diabetes, Diabetes
Therapuetic Areas:Cardiology / Vascular Diseases, Endocrinology, Gastroenterology, Other
Healthy:No
Age Range:25 - 80
Updated:1/20/2018
Start Date:September 1, 2017
End Date:December 31, 2020
Contact:Veronica Worth, MD
Email:cbernal@wustl.edu
Phone:3143620934

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This trial will evaluate whether a particular type of circulating white blood cell,
monocytes, from type 2 diabetics with high blood pressure and vitamin D deficiency vs.
sufficiency will induce hormones that increase blood pressure.

More than half of patients with type 2 diabetes mellitus develop hypertension, which doubles
their risk for cardiovascular disease. Inflammation plays a role in the development of these
diseases, and monocytes, a type of white blood cell, may be critical. This study will isolate
monocytes from blood samples of patients with type 2 diabetes and high blood pressure who
have either high levels of vitamin D or low levels of vitamin D, and determine what their
effects are on stimulating production in kidney cells of a hormone that increases blood
pressure.

Inclusion Criteria:

- Type 2 diabetes (T2DM)

- Age: 25-80 years old

- Vitamin 25(OH)D3 levels <20 or >30 ng/ml.

- HbA1c: 5.5%-9.5%

- Blood Pressure: <160/100 mm Hg on BP lowering medications and

- Blood Pressure: >120/80 to 160/100 mmHg without BP lowering medications

Exclusion Criteria:

- Recent weight loss of more than 5% within 3 months prior to screening

- Current Pregnancy

- Hypercalcemia

- Previous heart attack and stroke

- Heart failure

- Atrial fibrillation

- Heavy alcohol consumption

- Extreme diets (Atkins, South Beach)

- Chronic renal failure: stage 4 or worse

- >2 + proteinuria on urine sample

- Chronic diseases known to affect immunity
We found this trial at
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4921 Parkview Place
Saint Louis, Missouri 63110
Phone: 314-362-0934
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Saint Louis, Missouri 63110
Principal Investigator: Carlos Bernal-Mizrachi, MD
Phone: 314-362-0934
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