Remote Ischemic Preconditioning for Renal Protection in TAVI
| Status: | Recruiting |
|---|---|
| Conditions: | Renal Impairment / Chronic Kidney Disease, Cardiology, Nephrology |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Nephrology / Urology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 8/3/2018 |
| Start Date: | February 13, 2018 |
| End Date: | November 1, 2018 |
| Contact: | Brittany Fuller, MD |
| Email: | bfuller1@hfhs.org |
| Phone: | (313) 352-1177 |
Remote Ischemic Preconditioning for Renal Protection in Patients Undergoing Transcatheter Aortic Valve Interventions
Severe aortic stenosis remains a major cause of morbidity and mortality of the elderly
affecting approximately 3% of elderly patients with an increasing number of patients
undergoing transcatheter aortic valve interventions. As part of pre-procedural planning these
patients undergo CT scans and receive contrast during the procedure. These patients often
have baseline renal insufficiency and are high risk of contrast induced nephropathy despite
pre-hydration techniques. The purpose of this study is to evaluate the efficacy of this
simple and safe procedure in preventing renal injury in this particular population.
affecting approximately 3% of elderly patients with an increasing number of patients
undergoing transcatheter aortic valve interventions. As part of pre-procedural planning these
patients undergo CT scans and receive contrast during the procedure. These patients often
have baseline renal insufficiency and are high risk of contrast induced nephropathy despite
pre-hydration techniques. The purpose of this study is to evaluate the efficacy of this
simple and safe procedure in preventing renal injury in this particular population.
Inclusion Criteria:
- Adults aged 18 or older presenting with moderate to severe aortic stenosis for a
trans-catheter aortic valve intervention
Exclusion Criteria:
- Patients in cardiogenic shock defined as requiring circulatory or hemodynamic support
with a device, vasopressors or inotropes
- Systemic hypotension (systolic blood pressure < 90mmHg)
- Patients currently on hemodialysis
- Presence of an arteriovenous dialysis fistula or graft or lymphedema in either arm
- Patients enrolled in other active cardiovascular investigational studies
- Severe comorbidities with a life expectancy of less than 6 months
- Pregnant or lactating women
- Patients unable to provide consent
- Patients taking the medication glibenclamide for treatment of diabetes
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Henry Ford Hospital Founded in 1915 by auto pioneer Henry Ford and now one of...
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