Sleep and Pain in Sickle Cell Disease

The investigators propose to examine whether changes in sleep alter pain and pain-related
outcomes in adults with Sickle Cell Disease (SCD). As many as 70% of adults with SCD
experience various sleep disturbances. Pain and sleep are inter-related, such that pain
disturbs sleep and disturbed sleep amplifies pain and increases risk for developing chronic
pain. Pain processing occurs in the central nervous system, where nociceptive input can be
inhibited or facilitated and which can undergo both functional and structural plasticity.
When plasticity results in amplification of pain, this central sensitization (CS) manifests
as hyperalgesia, allodynia, and spreading of pain and is an important treatment target in its
own right. A growing literature implicates central sensitization in SCD, and the
investigators find a strong association between laboratory-evoked CS and sleep disturbance in
SCD. The neural substrates involved in pain modulation are often disrupted in chronic pain,
likely due to the demands pain places on cognitive resources, and similar effects are seen
with chronic insomnia. It remains unclear whether these changes occur in SCD and if improving
sleep improves central modulation of pain. The potential for improved sleep to reduce pain
and CS requires additional investigation, particularly given the significance of sleep
disturbance as a mutable risk factor. The investigators will conduct a randomized trial in
which it will be determined whether improvements in sleep reduce pain and alter brain
processing of pain and cognitive stimuli. The aims are to determine whether treatment of
sleep improves pain outcomes in SCD and to determine whether treatment of sleep alters
functional connectivity of cognitive and pain modulatory networks using brain imaging in SCD.

Inclusion Criteria:

- Diagnosis of sickle cell hemoglobinopathy (Homozygous sickle cell disease, Hemoglobin
SC disease, or Sickle/beta-thalassemia);

- Adequate facility with English;

- Stable dosing of medications (if taking) for pain and sleep;

- Reports symptoms of insomnia;

- Reports chronic pain

Exclusion Criteria:

- Cognitive impairment;

- Unstable psychiatric disorder;

- Seizure disorder;

- Positive pregnancy or drug test