Pembrolizumab and Chemoradiation Treatment for Advanced Cervical Cancer

Conditions:Cervical Cancer, Cervical Cancer, Cancer, Women's Studies
Therapuetic Areas:Oncology, Reproductive
Age Range:18 - Any
Start Date:January 2016
End Date:May 2021
Contact:Holly Davis

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A Randomized Phase II Study of Chemoradiation and Pembrolizumab for Locally Advanced Cancer

The purpose of this study is to evaluate the safety and effectiveness of immunotherapy in
combination with chemotherapy and radiation (chemoradiation) for the treatment of advanced
cervical cancer. Pembrolizumab, a type of immunotherapy called a checkpoint inhibitor, will
be administered after or during chemoradiation.

Inclusion Criteria:

- Confirmed cervical cancer.

- Must have adequate organ function.

Exclusion Criteria:

- Subject is pregnant.

- Recurrent cervical cancer.

- Distant metastases.

- Malignancy within the last 5 years; basal cell carcinoma or squamous cell carcinoma of
the skin that has undergone potentially curative therapy is permissable.

- Subject has had prior radiation, chemotherapy, targeted therapy, or investigational
therapy for cervical cancer.

- Subject has a immunodeficiency.

- Known history of HIV, Hepatitis B, Hepatitis C, TB, or inflammatory bowel disease.

- Hypersensitivity to pembrolizumab or similar drugs.

- Subject has an active autoimmune disease in the past 2 years.

- Known history of non-infectious pneumonitis.

- Subject has an active infection.

- Subject has known active central nervous system (CNS) metastases and/or carcinomatous
meningitis. Subjects with previously treated brain metastases are permissible. Talk to
Study Contact for specifics.
We found this trial at
3300 Gallows Road
Falls Church, Virginia 22042
(703) 776-4001
Phone: 703-208-6606
Inova Fairfax Hospital Inova Fairfax Hospital, Inova's flagship hospital, is an 833-bed, nationally recognized regional...
Falls Church, VA
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Baltimore, Maryland 21218
(410) 516-8000
Phone: 410-955-8849
Johns Hopkins The Johns Hopkins University opened in 1876, with the inauguration of its first...
Baltimore, MD
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Charlotte, North Carolina 28211
Phone: 980-442-2303
Charlotte, NC
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Charlottesville, Virginia 22903
(434) 924-0311
Principal Investigator: Linda Duska, MD
Phone: 434-924-2745
University of Virginia The University of Virginia is distinctive among institutions of higher education. Founded...
Charlottesville, VA
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1660 Springhill Avenue
Mobile, Alabama 36604
(251) 665-8000
Principal Investigator: Jennifer Scalici, MD
Phone: 251-445-9866
University of South Alabama Mitchell Cancer Institute USA Mitchell Cancer Institute (MCI) is located in...
Mobile, AL
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1100 N. Lindsay
Oklahoma City, Oklahoma 73104
(405) 271-4000
Phone: 405-271-8777
University of Oklahoma The OU Health Sciences Center is composed of seven health-related colleges located...
Oklahoma City, OK
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Richmond, Virginia 23298
(804) 828-0100
Virginia Commonwealth University Since our founding as a medical school in 1838, Virginia Commonwealth University...
Richmond, VA
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660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
Phone: 314-747-9202
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
Saint Louis, MO
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