An Investigational Immunotherapy Study of Nivolumab in Combination With Rucaparib, Docetaxel, or Enzalutamide in Metastatic Castration-resistant Prostate Cancer



Status:Recruiting
Conditions:Prostate Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:1/17/2019
Start Date:December 15, 2017
End Date:November 18, 2020
Contact:Recruiting sites have contact information. Please contact the sites directly. If there is no contact information,
Email:Clinical.Trials@bms.com
Phone:please email:

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A Phase 2 Study of Nivolumab in Combination With Either Rucaparib, Docetaxel, or Enzalutamide in Men With Castration-resistant Metastatic Prostate Cancer

The purpose of this study is to assess the safety and efficacy of nivolumab in combination
with rucaparib, docetaxel, or enzalutamide in participants with castration-resistant prostate
cancer that has spread.


For more information regarding Bristol-Myers Squibb Clinical Trial participation, please
visit www.BMSStudyConnect.com

Inclusion Criteria:

- Histologic confirmation of adenocarcinoma of the prostate

- Evidence of stage IV disease on previous bone, CT, and/or MRI scan

- Ongoing androgen deprivation therapy (ADT) with a gonadotropin-releasing hormone
(GnRH) analogue or bilateral orchiectomy

- Mandatory plasma and fresh or archival tumor tissue must be submitted

Exclusion Criteria:

- Prior malignancy active within the previous 3 years except for locally curable cancers
that have been apparently cured, such as basal or squamous cell skin cancer,
superficial bladder cancer, or carcinoma in situ of the breast

- Participants with active brain metastases

- Participants must have recovered from the effects of major surgery requiring general
anesthesia or significant traumatic injury at least 14 days before treatment arm
assignment

Other protocol defined inclusion/exclusion criteria could apply
We found this trial at
22
sites
Durham, North Carolina 27710
(919) 684-8111
Phone: 919-681-1030
Duke University Younger than most other prestigious U.S. research universities, Duke University consistently ranks among...
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Durham, NC
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4805 Northeast Glisan Street
Portland, Oregon 97213
(503) 215-1111
Phone: 503-215-2604
Providence Portland Medical Center We strive to give those we serve exceptional, compassionate health care...
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Portland, OR
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Allentown, Pennsylvania 18105
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Amsterdam, New York 12010
Phone: 518-262-2767
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Boston, Massachusetts 02118
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Boston, MA
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Caba, Buenos Aires
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Caba,
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Daphne, Alabama 36526
Phone: 251-607-5036
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Detroit, Michigan 48202
Phone: 313-576-9372
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Detroit, MI
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8503 Arlington Boulevard
Fairfax, Virginia 22031
Phone: 540-662-1108
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Jackson, Mississippi 39202
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Jackson, MS
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Louisville, Kentucky 40207
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Louisville, KY
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Marietta, Georgia 30060
Phone: 770-333-2161
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Marietta, GA
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Miami, Florida 33176
Phone: 786-596-7706
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Miami, FL
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Minneapolis, Minnesota 55416
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Minneapolis, MN
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333 Cedar St
New Haven, Connecticut 06504
(203) 432-4771
Phone: 203-785-6821
Yale University School of Medicine Founded in 1810, the Yale School of Medicine is a...
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New Orleans, Louisiana 70112
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Omaha, Nebraska 68130
Phone: 402-691-6971
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Omaha, NE
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Rancho Mirage, California
Phone: 7605683613110
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Rockville, Maryland 20850
Phone: 41096422121132
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Rockville, MD
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660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
Phone: 314-747-1343
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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San Francisco, California 94107
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