A Phase 2 Study Evaluating The Efficacy And Safety Of PF 04494700 In Mild To Moderate Alzheimer's Disease



Status:Completed
Conditions:Alzheimer Disease
Therapuetic Areas:Neurology
Healthy:No
Age Range:50 - Any
Updated:12/2/2018
Start Date:December 2007
End Date:December 2010

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Trial Summary
Trial Overview
Inclusion Criteria

A Double Blind, Placebo Controlled, Randomized, Multicenter Study Evaluating The Efficacy And Safety Of Eighteen Months Of Treatment With PF 04494700 (TTP488) In Participants With Mild To Moderate Alzheimer's Disease

The purpose of this study is to evaluate the efficacy and safety of PF 04494700 in
participants with mild to moderate Alzheimer's disease.


Inclusion Criteria:

- Mini Mental State Exam (MMSE) score between 14-26 (inclusive) at screening.

- Participants must be receiving acetylcholinesterase inhibitors on a stable dose for at
least 4 months prior to randomization

Exclusion Criteria:

- Current evidence or history of neurological, psychiatric and any other illness that
could contribute to non-Alzheimer's dementia.

- Known history of familial AD or any evidence for early onset AD known or possibly
associated with genetic mutations.

- Evidence or history of diabetes mellitus Type 1 or Type 2.

- History or symptoms of autoimmune disorders.
We found this trial at
43
sites
Pfizer Investigational Site
Jacksonville, Florida 32216
2135
mi
from 91732
Jacksonville, FL
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Pfizer Investigational Site
Ann Arbor, Michigan 48109
1934
mi
from 91732
Ann Arbor, MI
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Pfizer Investigational Site
Atlanta, Georgia 30309
1918
mi
from 91732
Atlanta, GA
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Pfizer Investigational Site
Baltimore, Maryland 21234
2305
mi
from 91732
Baltimore, MD
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Pfizer Investigational Site
Beachwood, Ohio 44122
?
mi
from 91732
Beachwood, OH
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Pfizer Investigational Site
Boston, Massachusetts 02115
2578
mi
from 91732
Boston, MA
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Pfizer Investigational Site
Charleston, South Carolina 29425
2183
mi
from 91732
Charleston, SC
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Pfizer Investigational Site
Chicago, Illinois 60611
1730
mi
from 91732
Chicago, IL
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Pfizer Investigational Site
Dallas, Texas 75204
1224
mi
from 91732
Dallas, TX
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Pfizer Investigational Site
Grand Rapids, Michigan 49506
1842
mi
from 91732
Grand Rapids, MI
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Pfizer Investigational Site
Houston, Texas 77030
1357
mi
from 91732
Houston, TX
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Pfizer Investigational Site
Indianapolis, Indiana 46234
1784
mi
from 91732
Indianapolis, IN
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Pfizer Investigational Site
Irvine, California 92606
28
mi
from 91732
Irvine, CA
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Pfizer Investigational Site
La Jolla, California 92037
95
mi
from 91732
La Jolla, CA
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Pfizer Investigational Site
Las Vegas, Nevada 89128
213
mi
from 91732
Las Vegas, NV
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Pfizer Investigational Site
Lexington, Kentucky 40504
1879
mi
from 91732
Lexington, KY
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Pfizer Investigational Site
Los Angeles, California 90027
25
mi
from 91732
Los Angeles, CA
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Pfizer Investigational Site
Madison, Wisconsin 53713
1655
mi
from 91732
Madison, WI
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Pfizer Investigational Site
Martinez, California 94553
?
mi
from 91732
Martinez, CA
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Miami Beach, Florida 33139
2324
mi
from 91732
Miami Beach, FL
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Nashville, Tennessee 37203
1762
mi
from 91732
Nashville, TN
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New Haven, Connecticut 06504
2485
mi
from 91732
New Haven, CT
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Pfizer Investigational Site
New York, New York 10029
2435
mi
from 91732
New York, NY
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Pfizer Investigational Site
Newport Beach, California 92663
31
mi
from 91732
Newport Beach, CA
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North Charleston, South Carolina 29406
2179
mi
from 91732
North Charleston, SC
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Pfizer Investigational Site
Orange, California 92868
21
mi
from 91732
Orange, CA
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Pfizer Investigational Site
Palo Alto, California 94304
326
mi
from 91732
Palo Alto, CA
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Philadelphia, Pennsylvania 19134
2378
mi
from 91732
Philadelphia, PA
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Pfizer Investigational Site
Phoenix, Arizona 85016
345
mi
from 91732
Phoenix, AZ
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Pittsburgh, Pennsylvania 15212
2118
mi
from 91732
Pittsburgh, PA
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Portland, Oregon 97210
830
mi
from 91732
Portland, OR
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Providence, Rhode Island 02905
2563
mi
from 91732
Providence, RI
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Rochester, New York 14642
2242
mi
from 91732
Rochester, NY
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Pfizer Investigational Site
Sacramento, California 95816
365
mi
from 91732
Sacramento, CA
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Saint Louis, Missouri 63139
1567
mi
from 91732
Saint Louis, MO
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Pfizer Investigational Site
Salt Lake City, Utah 84103
575
mi
from 91732
Salt Lake City, UT
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Pfizer Investigational Site
San Diego, California 92123
100
mi
from 91732
San Diego, CA
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Pfizer Investigational Site
San Francisco, California 94115
356
mi
from 91732
San Francisco, CA
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Pfizer Investigational Site
Seattle, Washington 98166
951
mi
from 91732
Seattle, WA
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Sun City, Arizona 85372
330
mi
from 91732
Sun City, AZ
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Pfizer Investigational Site
Tampa, Florida 33609
2133
mi
from 91732
Tampa, FL
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Pfizer Investigational Site
Vista, California 92083
74
mi
from 91732
Vista, CA
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Pfizer Investigational Site
Washington, District of Columbia 20003
2281
mi
from 91732
Washington,
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