A Phase 2 Study Evaluating The Efficacy And Safety Of PF 04494700 In Mild To Moderate Alzheimer's Disease



Status:Completed
Conditions:Alzheimer Disease
Therapuetic Areas:Neurology
Healthy:No
Age Range:50 - Any
Updated:12/2/2018
Start Date:December 2007
End Date:December 2010

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Trial Summary
Trial Overview
Inclusion Criteria

A Double Blind, Placebo Controlled, Randomized, Multicenter Study Evaluating The Efficacy And Safety Of Eighteen Months Of Treatment With PF 04494700 (TTP488) In Participants With Mild To Moderate Alzheimer's Disease

The purpose of this study is to evaluate the efficacy and safety of PF 04494700 in
participants with mild to moderate Alzheimer's disease.


Inclusion Criteria:

- Mini Mental State Exam (MMSE) score between 14-26 (inclusive) at screening.

- Participants must be receiving acetylcholinesterase inhibitors on a stable dose for at
least 4 months prior to randomization

Exclusion Criteria:

- Current evidence or history of neurological, psychiatric and any other illness that
could contribute to non-Alzheimer's dementia.

- Known history of familial AD or any evidence for early onset AD known or possibly
associated with genetic mutations.

- Evidence or history of diabetes mellitus Type 1 or Type 2.

- History or symptoms of autoimmune disorders.
We found this trial at
43
sites
Pfizer Investigational Site
Rochester, New York 14642
1121
mi
from
Rochester, NY
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Ann Arbor, Michigan 48109
810
mi
from
Ann Arbor, MI
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Atlanta, Georgia 30309
800
mi
from
Atlanta, GA
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Baltimore, Maryland 21234
1152
mi
from
Baltimore, MD
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Pfizer Investigational Site
Beachwood, Ohio 44122
?
mi
from
Beachwood, OH
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Boston, Massachusetts 02115
1444
mi
from
Boston, MA
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Charleston, South Carolina 29425
1062
mi
from
Charleston, SC
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Pfizer Investigational Site
Chicago, Illinois 60611
611
mi
from
Chicago, IL
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Pfizer Investigational Site
Dallas, Texas 75204
347
mi
from
Dallas, TX
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Pfizer Investigational Site
Grand Rapids, Michigan 49506
735
mi
from
Grand Rapids, MI
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Pfizer Investigational Site
Houston, Texas 77030
572
mi
from
Houston, TX
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Pfizer Investigational Site
Indianapolis, Indiana 46234
634
mi
from
Indianapolis, IN
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Pfizer Investigational Site
Irvine, California 92606
1153
mi
from
Irvine, CA
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Pfizer Investigational Site
Jacksonville, Florida 32216
1061
mi
from
Jacksonville, FL
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Pfizer Investigational Site
La Jolla, California 92037
1145
mi
from
La Jolla, CA
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Pfizer Investigational Site
Las Vegas, Nevada 89128
967
mi
from
Las Vegas, NV
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Pfizer Investigational Site
Lexington, Kentucky 40504
723
mi
from
Lexington, KY
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Pfizer Investigational Site
Los Angeles, California 90027
1177
mi
from
Los Angeles, CA
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Madison, Wisconsin 53713
574
mi
from
Madison, WI
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Pfizer Investigational Site
Martinez, California 94553
?
mi
from
Martinez, CA
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Pfizer Investigational Site
Miami Beach, Florida 33139
1323
mi
from
Miami Beach, FL
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Pfizer Investigational Site
Nashville, Tennessee 37203
618
mi
from
Nashville, TN
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Pfizer Investigational Site
New Haven, Connecticut 06504
1343
mi
from
New Haven, CT
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Pfizer Investigational Site
New York, New York 10029
1290
mi
from
New York, NY
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Newport Beach, California 92663
1161
mi
from
Newport Beach, CA
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North Charleston, South Carolina 29406
1056
mi
from
North Charleston, SC
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Orange, California 92868
1154
mi
from
Orange, CA
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Pfizer Investigational Site
Palo Alto, California 94304
1330
mi
from
Palo Alto, CA
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Pfizer Investigational Site
Philadelphia, Pennsylvania 19134
1228
mi
from
Philadelphia, PA
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Phoenix, Arizona 85016
848
mi
from
Phoenix, AZ
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Pittsburgh, Pennsylvania 15212
971
mi
from
Pittsburgh, PA
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Pfizer Investigational Site
Portland, Oregon 97210
1386
mi
from
Portland, OR
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Pfizer Investigational Site
Providence, Rhode Island 02905
1424
mi
from
Providence, RI
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Pfizer Investigational Site
Sacramento, California 95816
1281
mi
from
Sacramento, CA
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Pfizer Investigational Site
Saint Louis, Missouri 63139
412
mi
from
Saint Louis, MO
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Pfizer Investigational Site
Salt Lake City, Utah 84103
778
mi
from
Salt Lake City, UT
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Pfizer Investigational Site
San Diego, California 92123
1138
mi
from
San Diego, CA
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Pfizer Investigational Site
San Francisco, California 94115
1340
mi
from
San Francisco, CA
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Pfizer Investigational Site
Seattle, Washington 98166
1407
mi
from
Seattle, WA
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Pfizer Investigational Site
Sun City, Arizona 85372
857
mi
from
Sun City, AZ
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Pfizer Investigational Site
Tampa, Florida 33609
1115
mi
from
Tampa, FL
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Pfizer Investigational Site
Vista, California 92083
1135
mi
from
Vista, CA
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Pfizer Investigational Site
Washington, District of Columbia 20003
1127
mi
from
Washington,
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