Effects of Dietary Supplement Tauroursodeoxycholic Acid on Vascular Function
| Status: | Recruiting |
|---|---|
| Conditions: | Diabetes, Diabetes |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 20 - 65 |
| Updated: | 11/8/2017 |
| Start Date: | October 28, 2015 |
| End Date: | September 12, 2018 |
| Contact: | Jaume Padilla, PhD |
| Email: | padillaja@missouri.edu |
| Phone: | 812 3453566 |
Targeting Endoplasmic Reticulum Stress to Correct Vascular Insulin Resistance and Glycemic Dysregulation
The purpose of the present study is to determine if use of dietary supplement
tauroursodeoxycholic acid enhances insulin-stimulated leg blood flow and glucose disposal.
tauroursodeoxycholic acid enhances insulin-stimulated leg blood flow and glucose disposal.
The notion that cellular stress lowers insulin-induced vasodilation is largely founded on ex
vivo studies and experiments in rodents. However, it remains unknown if maintenance of
cellular function with the use of dietary supplement tauroursodeoxycholic acid enhances
vascular function in humans. The investigators test the hypothesis that daily administration
of this dietary supplement enhances vascular function, particularly, insulin-stimulated leg
blood flow and glucose disposal.
vivo studies and experiments in rodents. However, it remains unknown if maintenance of
cellular function with the use of dietary supplement tauroursodeoxycholic acid enhances
vascular function in humans. The investigators test the hypothesis that daily administration
of this dietary supplement enhances vascular function, particularly, insulin-stimulated leg
blood flow and glucose disposal.
Inclusion Criteria:
- Type 2 diabetes diagnosed by primary physician
- Body mass index less then 43 kg/m2
Exclusion Criteria:
- Recent weight gain or loss (>5% body weight in the last 3 months)
- Pregnancy
- Consumption of >14 alcoholic beverages per week
- Changes in the medication use or dose within the last 3 months
- Known cardiovascular or pulmonary disease
- Taking medication for advanced retinopathy or neuropathy
- Taking prescription anticoagulants
- Nicotine use
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