Exercise Effect on Chemotherapy-Induced Neuropathic Pain
| Status: | Recruiting |
|---|---|
| Conditions: | Breast Cancer, Lung Cancer, Colorectal Cancer, Ovarian Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 21 - 70 |
| Updated: | 2/15/2018 |
| Start Date: | March 1, 2018 |
| End Date: | June 2018 |
| Contact: | Kathleen Griffith, CRNP, PhD |
| Email: | kgriffith@gwu.edu |
| Phone: | 202-994-0025 |
Exercise Effect on Chemotherapy-Induced Neuropathic Pain, Peripheral Nerve Fibers
Chemotherapy-induced peripheral neuropathy (CIPN) continues to be a serious healthcare
concern. It is painful, persistent, resistant to conventional pain therapies, and results in
long-term suffering and decreased quality of life for many cancer survivors. The role of
exercise to decrease CIPN-related neuropathic pain (CIPN-NP) will be investigated, with the
goal of identifying the mechanisms associated with this therapeutic approach to manage
CIPN-NP.
concern. It is painful, persistent, resistant to conventional pain therapies, and results in
long-term suffering and decreased quality of life for many cancer survivors. The role of
exercise to decrease CIPN-related neuropathic pain (CIPN-NP) will be investigated, with the
goal of identifying the mechanisms associated with this therapeutic approach to manage
CIPN-NP.
Inclusion Criteria:
- Diagnosis with cancer, stage I-IV
- History of treatment with oxaliplatin, docetaxel, or paclitaxel, either alone or in
combination with other agents
- Completion of chemotherapy > 6 months < 1 year
- Ability to walk on a treadmill
- Medical clearance from oncologist or primary care provider
- Presence of CIPN per National Cancer Institute Common Toxicity Criteria grade 1-3
(0-no signs/symptoms, 1-minor loss of function, 2-increased symptoms not interfering
with activities of daily living (ADLs), 3-severe symptoms interfering with ADL,
4-disabling, and 5 is death)
- Score on Neuropathic Pain Scale >1
- Age 21-70
Exclusion Criteria:
- Denial of CIPN
- Other motor/sensory neuropathy caused by other than chemotherapy (i.e.alcohol-related,
autoimmune diseases, diabetes)
- Coronary artery disease
- History of >1 chemotherapy regimen
- Musculoskeletal conditions which preclude participation in an exercise training
program
- Pregnancy
- Regular exerciser, defined as >90 minutes per week of aerobic exercise and any
resistive training
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