Intercostal Liposomal Bupivacaine for the Management of Blunt Chest Wall Trauma

The purpose of this study is to evaluate the efficacy of liposomal bupivacaine to provide
analgesia via paravertebral intercostal nerve block following significant blunt chest trauma,
minimizing adverse outcomes, length of stay and overall narcotic use. The primary outcome of
the study is to compare requirements between the bupivacaine group and a standard-of-care
group.

Inclusion Criteria:

- Anticipated length of stay of at least 72 hours

- Blunt chest wall trauma with two or more rib or sternal fractures

- Demonstrated ability to achieve > 50% predicted inspiratory capacity based on ideal
body weight using IS within the first 24 hours of admission

Exclusion Criteria:

- Known allergy to bupivacaine

- Respiratory failure requiring intubation within 24 hours prior to enrollment

- Known or suspected atrioventricular nodal blockade process requiring cardiology
evaluation or pacemaker placement

- Hemodynamic instability (defined as new intravenous vasopressor or inotrope
requirement or mean arterial pressure < 55 mmHg)

- Signs of active myocardial ischemia or non-ST elevation MI

- > 20 rib fractures

- Weight < 50 kg or > 150 kg

- Pregnancy

- Incarceration