Effects of Retinoids on CYP2D6 Activity During Pregnancy
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 18 - 50 |
| Updated: | 4/25/2018 |
| Start Date: | July 25, 2017 |
| End Date: | April 24, 2027 |
| Contact: | Mary F Hebert, PharmD |
| Email: | mhebert@uw.edu |
| Phone: | 206-697-2138 |
Effects of Retinoids on CYP2D6 Activity and Variability in Special Populations
Prospective drug interaction study during pregnancy.
A randomized pharmacokinetic study to evaluate CYP2D6 activity with and without vitamin A
administration during pregnancy and compared to postpartum control.
administration during pregnancy and compared to postpartum control.
Inclusion Criteria:
- Singleton pregnancies
- Extensive metabolizers
Exclusion Criteria:
- Chronic or persistent cough accompanying asthma, smoking or chronic obstructive
pulmonary disease
- Productive cough
- Fever
- Known kidney disease
- Known liver disease
- Diabetes
- Obesity
- Bipolar disease
- Attention deficit disorder
- Social phobia
- Allergy or history of adverse event with dextromethorphan
- Drugs, foods, beverages or dietary supplements that interact with CYP2D6 or
dextromethorphan
- dextromethorphan
- Unable to give written informed consent
- Inability to fast
- Concurrent use of vitamin A supplementation
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