Lung Fluid and Peripheral Blood Neutrophil IL-5 Surface Receptor in Children With Asthma



Status:Enrolling by invitation
Conditions:Asthma
Therapuetic Areas:Pulmonary / Respiratory Diseases
Healthy:No
Age Range:Any - 17
Updated:10/28/2017
Start Date:August 2016
End Date:August 2019

Use our guide to learn which trials are right for you!

The pattern of lower airway inflammation in asthma is heterogeneous, but in many patients,
the polymorphonuclear neutrophil (PMN) is the predominant granulocyte infiltrating the
airspaces. Although it is known to have an important function in innate immune defense, the
role of the PMN in asthma has not been well elucidated. In work in progress, the
investigators have identified the receptor for IL-5 on the surface of bronchoalveolar lavage
(BAL) PMNs in a subset of children with severe, treatment-resistant asthma, a characteristic
that is not found in peripheral blood neutrophils. While the function of this IL-5 receptor
has yet to be determined, preliminary evidence strongly supports a mechanism linking
neutrophilic with type 2 inflammation in the lower airways of children with asthma, a
discovery that has exciting potential to modify the treatment of asthma.

The primary objective of this observational cross-sectional study is to test the overall
hypothesis that therapeutic intervention directed against the IL-5R on lung PMNs will
decrease inflammation and improve clinical outcomes in patients with poorly controlled
asthma. The secondary study objective is to demonstrate that IL-5R expression on
lung-infiltrating PMNs is functional, will activate known IL-5R-induced signaling pathways,
and will lead to enhanced PMN pro-inflammatory activity including increased PMN recruitment,
prolonged survival, degranulation, and release of reactive oxygen species.


Inclusion Criteria:

- Ages 0-17

- Treatment-resistant, refractory respiratory symptoms

- Scheduled for a clinical diagnostic bronchoscopy

Exclusion Criteria:

- Known lower respiratory tract infection within 60 days of scheduled bronchoscopy

- Systemic disorders involving the heart, respiratory system, CNS, renal, and endocrine
systems
We found this trial at
1
site
1215 Lee St
Charlottesville, Virginia 22903
(434) 924-0211
University of Virginia Health System UVA Health System includes a 604-bed hospital, level I trauma...
?
mi
from
Charlottesville, VA
Click here to add this to my saved trials