Improving Pulmonary Function Following Radiation Therapy



Status:Recruiting
Conditions:Lung Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:3/8/2019
Start Date:August 2016
End Date:December 2023
Contact:Cancer Connect
Email:cancerconnect@uwcarbone.wisc.edu
Phone:800-622-8922

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The purpose of this study is to develop radiation plans that will help preserve lung function
in healthy tissue surrounding the tumor. We believe that 4DCT scans can be useful in
designing radiation treatment plans that help us avoid healthy normal functioning lung tissue
close to lung tumors. Currently 4DCT scans are used to help us determine exactly where the
tumor is and how it moves when you breathe. In this study we will also use the 4DCT scans to
try to identify high functioning normal lung tissue.


Inclusion Criteria:

- Histologic diagnosis of non-small cell lung cancer or lung metastasis from a solid
tumor. One biopsy site is adequate for multiple sites of thoracic disease.

- Treatment includes localized radiation therapy with or without chemotherapy

- Karnofsky ≥ 60%

- Not pregnant per radiation oncology standard procedures

- Ability to understand and the willingness to sign a written informed consent document

Exclusion Criteria:

- Prior (within last 6 months) or future planned therapeutic surgery for the treatment
of the existing lung cancer

- Prior thoracic radiotherapy

- Severe COPD defined as disease requiring an inpatient stay for respiratory
deterioration within the past 3 months

- Oxygen dependence of > 2 L/min continuously throughout the day at baseline

- Known underlying collagen vascular disease or intrinsic lung disease that could
complicate expected sequelae of radiation (idiopathic pulmonary fibrosis, Wegener's
granulomatosis)

- Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
arrhythmia, or psychiatric illness/social situations that would limit compliance with
study requirements.
We found this trial at
2
sites
250 Doctors Court
Johnson Creek, Wisconsin 53038
Principal Investigator: Jessica Schuster
Phone: 920-699-3500
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600 Highland Ave.
Madison, Wisconsin 53792
(608) 263-6400
Principal Investigator: John Bayouth
Phone: 800-622-8922
University of Wisconsin Carbone Cancer Center UW Carbone Cancer Center holds the unique distinction of...
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