Effects of EED on Zn Absorption and Retention in Children From a Standard Dose



Status:Active, not recruiting
Conditions:Food Studies, Ocular, Metabolic
Therapuetic Areas:Ophthalmology, Pharmacology / Toxicology
Healthy:No
Age Range:Any
Updated:5/23/2018
Start Date:November 2015
End Date:June 2019

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Effects of Environmental Enteric Dysfunction (EED) on Zinc (Zn) Absorption and Retention in Young Children: Study 1 - Absorption of Zn and Vitamin A From a Standard Dose

The overall objective is to determine the impact of EED on zinc absorption and homeostasis,
and its impact on the absorptive capacity of vitamin A absorption of young children (18-24
months of age) in an austere setting with high rates of diarrhea, stunting, and
micro-nutrient deficiencies.

Participating children are screened for EED using the lactulose:mannitol ratio test and
assigned to one of two groups: +EED or -EED. All participants will be given standard,
physiological dose of 3 mg zinc sulfate with a zinc stable isotope tracer on study day 8.

On study day 11, 0.5 mg of 13C10-retinyl-acetate will be administered orally to all
participants.

Spot urine samples will be collected twice daily from study days 11-14. Complete fecal
collections will be obtained for days 11-14. Duplicate diets of all foods consumed will be
collected on days 11-14. On study day 14, a blood sample will be taken for analysis of
vitamin A isotope status.

Inclusion Criteria:

- Absence of apparent health problems that would impair ability to consume regular diet,
to tolerate zinc supplements, or to comply with demands of metabolic studies

- Length for age Z-score (LAZ) between -1.5 to -3.0

- Hemoglobin (Hgb) ≥ 8

Exclusion Criteria:

- Outside age range

- Hgb < 8

- Chronic illness

- Recent diarrhea (within past 2 weeks, treated with supplemental zinc)

- Severe stunting and/or severe acute malnutrition (SAM): LAZ <-3; Weight-for-age
Z-score (WHZ) <-3 or mid-upper arm circumference (MUAC) < 115 or edema
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