Clinician Utilization of Corus CAD (or ASGES) in Primary Care Provider Decision Making

This retrospective study will investigate clinician behavior in diagnosing patients with
possible obstructive coronary artery disease who received a Corus CAD (Age/Sex/Gene
Expression score - ASGES) result compared to patients who did not have the test performed
(matched control patients). The data collected will be from primary care practices and will
also assess one to two year health outcomes (MACE, procedure complications). Furthermore, in
these real world practice settings, the study will investigate the economic impact of Corus
CAD (ASGES) usage at each practice using practice specific data, when available.

Inclusion Criteria:

For Corus CAD (Age/Sex/Gene Expression score - ASGES) arm:

- Symptoms suggestive of obstructive CAD, according to the opinion of the site clinician

- Age >= 21 years

- Resulted Corus CAD (ASGES) test used during the evaluation and/or diagnosis of
symptoms suggestive of obstructive coronary artery disease (CAD), preferably 1 year
prior to data collection date.

For Control arm:

- Symptoms suggestive of obstructive CAD, according to the opinion of the site clinician

- Eligible for Corus CAD (ASGES) (see exclusion criteria)

- Matched to Corus CAD (ASGES) patients by sex, age +/-2.5 years, and presenting
symptoms

Exclusion Criteria:

- History of myocardial infarction (MI) or CAD prior to the index evaluation

- Presentation of high risk unstable angina for the index evaluation

- Concurrent systemic infection or inflammatory process

- Concurrent MI or acute coronary syndrome

- Known diabetes mellitus diagnosis or laboratory test results suggestive of a diagnosis
of diabetes mellitus (e.g., HbA1C >=6.5)

- Use of steroids, immunosuppressive agents, or chemotherapeutic agents, at time of
chest pain presentation