Theta Burst Stimulation to Promote Motor Re-education in Tetraplegia
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 7/26/2018 |
| Start Date: | April 16, 2018 |
| End Date: | June 30, 2019 |
| Contact: | Carrie L Peterson, PhD |
| Email: | clpeterson@vcu.edu |
| Phone: | 8048275270 |
Intermittent Theta Burst Stimulation to Promote Motor Re-education After Upper Limb Reconstruction in Tetraplegia
A repetitive, non-invasive brain stimulation technique referred to as theta burst stimulation
can modulate corticomotor excitability and therefore has great rehabilitative potential for
individuals with neurologic deficits, including individuals with spinal cord injury (SCI). In
particular, intermittent theta burst stimulation (iTBS) can increase corticomotor
excitability and may be a useful adjunct to physical rehabilitation to promote motor
re-education after upper limb reconstruction in individuals with tetraplegia. Upper limb
reconstruction involves surgical transfer of a non-paralyzed tendon or nerve with a redundant
or less important function to perform a more critical function. Upper limb reconstruction is
intended to help individuals achieve their goals related to activities of daily living and
independence in the community. Outcomes after reconstruction are variable and depend largely
on the efficacy of motor re-education of the transferred muscle to perform a new function.
The long-term goal of our research is to determine whether iTBS combined with physical
rehabilitation can improve motor re-education after reconstruction. As a first step, the
purpose of this proposal is to determine the effect of iTBS on corticomotor excitability of
proximal muscles in nonimpaired individuals and two groups of individuals with tetraplegia:
individuals with and without upper limb reconstruction.
can modulate corticomotor excitability and therefore has great rehabilitative potential for
individuals with neurologic deficits, including individuals with spinal cord injury (SCI). In
particular, intermittent theta burst stimulation (iTBS) can increase corticomotor
excitability and may be a useful adjunct to physical rehabilitation to promote motor
re-education after upper limb reconstruction in individuals with tetraplegia. Upper limb
reconstruction involves surgical transfer of a non-paralyzed tendon or nerve with a redundant
or less important function to perform a more critical function. Upper limb reconstruction is
intended to help individuals achieve their goals related to activities of daily living and
independence in the community. Outcomes after reconstruction are variable and depend largely
on the efficacy of motor re-education of the transferred muscle to perform a new function.
The long-term goal of our research is to determine whether iTBS combined with physical
rehabilitation can improve motor re-education after reconstruction. As a first step, the
purpose of this proposal is to determine the effect of iTBS on corticomotor excitability of
proximal muscles in nonimpaired individuals and two groups of individuals with tetraplegia:
individuals with and without upper limb reconstruction.
Inclusion Criteria for all subjects with tetraplegia:
- Injury to the lower cervical spinal cord at least one year prior to the date of
participation
- Motor function classified according to the American Spinal Injury Association
International Standards for Neurological Classification of Spinal Cord Injury at
levels ranging from C5-C8
Inclusion criteria for the subjects with tetraplegia and upper limb reconstruction:
• At least one year post-operative from tendon or nerve transfer surgery of the upper limb
Exclusion criteria for all subjects with tetraplegia:
- Presence of concurrent severe medical illness, including unhealed decubiti, use of
baclofen pumps, existing infection, cardiovascular disease, significant osteoporosis,
or a history of pulmonary complications.
- Metal implant near head or neck
- Risk of seizure of history of seizures
We found this trial at
1
site
Richmond, Virginia 23298
(804) 828-0100
Principal Investigator: Carrie L Peterson, PhD
Phone: 804-827-5270
Virginia Commonwealth University Since our founding as a medical school in 1838, Virginia Commonwealth University...
Click here to add this to my saved trials
