Study of GBR 1342, a CD38/CD3 Bispecific Antibody, in Subjects With Previously Treated Multiple Myeloma



Status:Recruiting
Conditions:Blood Cancer, Hematology, Hematology
Therapuetic Areas:Hematology, Oncology
Healthy:No
Age Range:18 - Any
Updated:12/14/2018
Start Date:October 16, 2017
End Date:April 2020
Contact:Vilia Dragovoy
Email:clinicaltrialsdisclosuredesk@glenmarkpharma.com
Phone:(201) 684-8000

Use our guide to learn which trials are right for you!

A Phase 1, First-in-Man, Multicenter, Open-Label, Two Part Dose- Escalation and Cohort Expansion Study of Single-Agent GBR 1342 in Subjects With Previously Treated Multiple Myeloma

The purpose of this study is to determine the safety profile and maximum tolerable dose (MTD)
of single-agent GBR 1342 in subjects with multiple myeloma who have received prior therapies.


Inclusion Criteria:

- Males or females with multiple myeloma who have exhausted available standard
therapies.

- Measurable disease, defined as any quantifiable monoclonal protein value

- ECOG performance-status score of 2 or less

- Life expectancy of at least 3 months

- Recovered from any previous surgery and no history of major surgery within the last 28
days prior to start of study drug

Exclusion Criteria:

- Any condition that, in the opinion of the Investigator, would interfere with
evaluation of the study drug or interpretation of subject safety or study results.

- Active infectious disease considered by the Investigator to be incompatible with the
protocol.

- Evidence of clinically significant cardiovascular and respiratory conditions

- Anti-myeloma treatment within 2 weeks

- Use of any investigational drug within the past 4 weeks
We found this trial at
7
sites
Baltimore, Maryland 21287
2301
mi
from 91732
Baltimore, MD
Click here to add this to my saved trials
Denver, Colorado 80218
?
mi
from 91732
Denver, CO
Click here to add this to my saved trials
Hackensack, New Jersey 07601
2430
mi
from 91732
Hackensack, NJ
Click here to add this to my saved trials
Little Rock, Arkansas 72205
1463
mi
from 91732
Little Rock, AR
Click here to add this to my saved trials
Madison, Wisconsin 53792
?
mi
from 91732
Madison, WI
Click here to add this to my saved trials
Nashville, Tennessee
1763
mi
from 91732
Nashville, TN
Click here to add this to my saved trials
New York, New York 10029
2351
mi
from 91732
New York, NY
Click here to add this to my saved trials